Related Product Information for anti-STMN3 antibody
The protein encoded by this gene belongs to the stathmin/oncoprotein 18 family of microtubule-destabilizing phosphoproteins. It is similar to the SCG10 protein and is involved in signal transduction and regulation of microtubule dynamics.
Product Categories/Family for anti-STMN3 antibody
References
Ng, D.C., et al. Biochem. J. 425(1):95-105(2010). Mahapatra, N.R., et al. Biochemistry 47(27):7167-7178(2008). Bieche, I., et al. Genomics 81(4):400-410(2003). Deloukas, P., et al. Nature 414(6866):865-871(2001). Charbaut, E., et al. J. Biol. Chem. 276(19):16146-16154(2001).
NCBI Description
This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form a complex with tubulins at a ratio of 2 tubulins for each stathmin protein. Microtubules require the ordered assembly of alpha- and beta-tubulins, and formation of a complex with stathmin disrupts microtubule formation and function. A pseudogene of this gene is located on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Uniprot Description
STMN3: Exhibits microtubule-destabilizing activity, which is antagonized by STAT3. Belongs to the stathmin family.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 20q13.3
Cellular Component: Golgi apparatus; neuron projection; growth cone; axon; cytoplasm
Molecular Function: tubulin binding; protein domain specific binding
Biological Process: negative regulation of Rac protein signal transduction; nervous system development; microtubule depolymerization; regulation of microtubule polymerization or depolymerization; cytoplasmic microtubule organization and biogenesis; neurite development; regulation of cytoskeleton organization and biogenesis
Product Notes
The STMN3 stmn3 (Catalog #
AAA6352137) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The STMN3, CT (STMN3, SCLIP, Stathmin-3, SCG10-like protein) (AP) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's STMN3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:100-500 ELISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the STMN3 stmn3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"STMN3, Polyclonal Antibody" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
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