Rabbit anti-Human, Mouse STEAP2 Polyclonal Antibody | anti-STEAP2 antibody

STEAP2 Antibody

Cat. Num. AAA9406615

• Gene Names: STEAP2; STMP; IPCA1; PUMPCn; STAMP1; PCANAP1
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: STEAP2; Polyclonal Antibody; STEAP2 Antibody; Six transmembrane epithelial antigen of prostate 2; anti-STEAP2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: This STEAP2 antibody does not cross-react with other STEAP proteins.
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 490

• Applicable Applications for anti-STEAP2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 16 amino acid peptide from near the carboxy terminus of human STEAP2.
• Target Name: STEAP2
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of STEAP2 in human prostate tissue lysate with STEAP2 antibody at 1 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of STEAP2 in human colon tissue with STEAP2 antibody at 2.5 ug/mL.)

Related Product Information for anti-STEAP2 antibody

The six-transmembrane epithelial antigen of prostate 2 (STEAP2) is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. Similar to two other members of the STEAP family (STEAP 3 and STEAP4), STEAP2 promotes both iron and copper reduction. STEAP2 expression in transfected cells also correlated with iron or copper uptake, suggesting that the STEAP family of proteins may function to stimulate iron and copper uptake. STEAP2 is widely expressed in many tissues in the plasma membrane, but is most highly expressed in prostate. At least three isoforms of STEAP2 are known to exist.

Product Categories/Family for anti-STEAP2 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 100913194
• NCBI GeneID: 261729
• NCBI Accession #: NP_001035755.1
• NCBI GenBank Nucleotide #: NM_001040665.1
• UniProt Accession #: Q8NFT2; Q6UXN6; Q6YPB1; Q8IUE7; A4D1F1; G5E9C6
• Molecular Weight: 47,916 Da
• NCBI Official Full Name: metalloreductase STEAP2 isoform a
• NCBI Official Synonym Full Names: STEAP family member 2, metalloreductase
• NCBI Official Symbol: STEAP2
• NCBI Official Synonym Symbols: STMP; IPCA1; PUMPCn; STAMP1; PCANAP1
• NCBI Protein Information: metalloreductase STEAP2
• UniProt Protein Name: Metalloreductase STEAP2
• Protein Family: Metalloreductase
• UniProt Gene Name: STEAP2
• UniProt Synonym Gene Names: PCANAP1; STAMP1; PUMPCn
• UniProt Entry Name: STEA2_HUMAN

NCBI Description

This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

STEAP2: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Belongs to the STEAP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.16.1.-; Vesicle; Membrane protein, multi-pass; Membrane protein, integral; Oxidoreductase

Chromosomal Location of Human Ortholog: 7q21.13

Cellular Component: trans-Golgi network transport vesicle; intracellular membrane-bound organelle; early endosome; plasma membrane; integral to Golgi membrane; endosome membrane; cytosol

Molecular Function: transporter activity; metal ion binding; cupric reductase activity

Biological Process: Golgi to plasma membrane transport; regulated secretory pathway; iron ion homeostasis; response to hormone stimulus; copper ion import; endocytosis