Rabbit anti-Human STAT3 Polyclonal Antibody | anti-STAT3 antibody

STAT3 Antibody

Cat. Num. AAA9415388

• Gene Names: STAT3; APRF; HIES; ADMIO
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen Affinity Purification
• Synonyms: STAT3; Polyclonal Antibody; STAT3 Antibody; APRF; HIES; ADMIO; anti-STAT3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total STAT3 protein.
• Purity/Purification: Antigen Affinity Purification
• Form/Format: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Concentration: 0.6 mg/ml (varies by lot)
• Sequence Length: 769

• Applicable Applications for anti-STAT3 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:25-1:100
• Immunogen: Fusion protein of human STAT3
• Immunogen Type: Protein
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using at dilution 1/20.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using at dilution 1/20.)

Related Product Information for anti-STAT3 antibody

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein.PIAS3 protein is a specific inhibitor of this protein.Three alternatively spliced transcript variants encoding distinct isoformshave been described.

Product Categories/Family for anti-STAT3 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 21618338
• NCBI GeneID: 6774
• NCBI Accession #: NP_003141.2
• NCBI GenBank Nucleotide #: NM_003150.3
• UniProt Accession #: P40763; O14916; Q9BW54; A8K7B8; K7ENL3
• Molecular Weight: 83,126 Da
• NCBI Official Full Name: signal transducer and activator of transcription 3 isoform 2
• NCBI Official Synonym Full Names: signal transducer and activator of transcription 3
• NCBI Official Symbol: STAT3
• NCBI Official Synonym Symbols: APRF; HIES; ADMIO
• NCBI Protein Information: signal transducer and activator of transcription 3
• UniProt Protein Name: Signal transducer and activator of transcription 3
• Protein Family: Signal transducer and activator of transcription
• UniProt Gene Name: STAT3
• UniProt Entry Name: STAT3_HUMAN

Uniprot Description

STAT3: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Constitutively active in a number of human tumors. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.

Protein type: DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor

Chromosomal Location of Human Ortholog: 17q21.31

Cellular Component: cytoplasm; cytosol; nuclear chromatin; nucleoplasm; nucleus; plasma membrane

Molecular Function: chromatin DNA binding; DNA binding; identical protein binding; ligand-dependent nuclear receptor activity; protein binding; protein dimerization activity; protein kinase binding; protein phosphatase binding; signal transducer activity; transcription factor activity; transcription factor binding

Biological Process: astrocyte differentiation; cell motility; cellular response to hormone stimulus; eating behavior; eye photoreceptor cell differentiation; glucose homeostasis; intracellular receptor-mediated signaling pathway; JAK-STAT cascade; leptin-mediated signaling pathway; miRNA-mediated gene silencing, negative regulation of translation; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; nervous system development; phosphorylation; positive regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of Stat3 protein; protein import into nucleus; radial glial cell differentiation; regulation of cell cycle; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to estradiol stimulus; sexual reproduction; signal transduction; somatic stem cell maintenance; thermoregulation

Disease: Autoimmune Disease, Multisystem, Infantile-onset; Hyper-ige Recurrent Infection Syndrome, Autosomal Dominant