Western Blot (WB)
(WB Suggested Anti-STAP1 AntibodyTitration: 1.0 ug/mlPositive Control: HCT15 Whole Cell)
Rabbit STAP1 Polyclonal Antibody | anti-STAP1 antibody
STAP1 Antibody - middle region
Western Blot (WB)
(WB Suggested Anti-STAP1 AntibodyTitration: 1.0 ug/mlPositive Control: HCT15 Whole Cell)
Western Blot (WB)
(WB Suggested Anti-STAP1 AntibodyTitration: 1.0 ug/mlPositive Control: HCT15 Whole Cell)
Target Description: The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a postive feedback loop, increasing Tec activity.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene contains a proline-rich region, a pleckstrin homology (PH) domain, and a region in the carboxy terminal half with similarity to the Src Homology 2 (SH2) domain. This protein is a substrate of tyrosine-protein kinase Tec, and its interaction with tyrosine-protein kinase Tec is phosphorylation-dependent. This protein is thought to participate in a positive feedback loop by upregulating the activity of tyrosine-protein kinase Tec. Variants of this gene have been associated with autosomal-dominant hypercholesterolemia (ADH), which is characterized by elevated low-density lipoprotein cholesterol levels and in increased risk of coronary vascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Description
STAP1: an adaptor protein which contains pleckstrin homology (PH) and Src homology 2-like (SRC) domains and a proline-rich region. Induced in activated bone marrow-derived macrophages, and by CpG, LPS, and interferon in myeloid cell lines. Induces pro-inflammatory responses and may contribute to neuronal apoptosis and degeneration. Overexpressed, it interacts with the CSFR, inhibiting its ligand-dependent phosphorylation. Its expression inhibits cellular migration and can increase cytotoxicity against 661W photoreceptor like cells.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 4q13.2
Cellular Component: protein complex; mitochondrion; cytoplasm; nucleus
Molecular Function: protein binding; SH3/SH2 adaptor activity
Biological Process: intracellular protein transport; positive regulation of signal transduction; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on STAP1
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Product Notes
The STAP1 stap1 (Catalog #AAA3217204) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The STAP1 Antibody - middle region reacts with Horse, Human, Rabbit, Yeast and may cross-react with other species as described in the data sheet. AAA Biotech's STAP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the STAP1 stap1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: TELSVPQNVS LLPGQVIKLH EVLEREKKRR IETEQSTSVE KEKEPTEDYV. It is sometimes possible for the material contained within the vial of "STAP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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