Western Blot (WB)
(SSH1 Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the SSH1 antibody detected the SSH1 protein (arrow).)
Rabbit SSH1 Polyclonal Antibody | anti-SSH1 antibody
SSH1 Antibody (N-term)
Western Blot (WB)
(SSH1 Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the SSH1 antibody detected the SSH1 protein (arrow).)
Western Blot (WB)
(SSH1 Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the SSH1 antibody detected the SSH1 protein (arrow).)
MIM 601442) is composed of stimulus-responsive mediators of actin
dynamics. ADF/cofilin proteins are inactivated by kinases such as
LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to
play a role in actin dynamics by reactivating ADF/cofilin proteins
in vivo (Niwa et al., 2002 [PubMed 11832213]).
Peterburs, P., et al. Cancer Res. 69(14):5634-5638(2009)
Kligys, K., et al. Biochem. Biophys. Res. Commun. 383(4):450-454(2009)
Kim, J.S., et al. Mol. Biol. Cell 20(11):2650-2660(2009)
Huang, T.Y., et al. Dev. Cell 15(5):691-703(2008)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Uniprot Description
SSH1: a dual-specificity phosphatase of the Slingshot family involved in actin reorganization. Its calcineurin-dependent activation dephosphorylates cofilin. Plays a role in later stages of mitosis by dephosphorylating and activating cofilin.
Protein type: Protein phosphatase, dual-specificity; EC 3.1.3.16; EC 3.1.3.48
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component: nucleoplasm; cytoskeleton; lamellipodium; cytoplasm; plasma membrane; midbody; cleavage furrow
Molecular Function: protein binding; DNA binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; actin binding; phosphoprotein phosphatase activity
Biological Process: regulation of cellular protein metabolic process; regulation of actin polymerization and/or depolymerization; cell morphogenesis; actin cytoskeleton organization and biogenesis; protein amino acid dephosphorylation; regulation of axonogenesis
Research Articles on SSH1
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Product Notes
The SSH1 ssh1 (Catalog #AAA9205789) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 227-254. The SSH1 Antibody (N-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's SSH1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the SSH1 ssh1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SSH1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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