SREBP-1 Polyclonal Antibody | anti-SREBP-1 antibody

SREBP-1 (Acetyl-Lys324) Polyclonal Antibody

Cat. Num. AAA8537434

• Gene Names: SREBF1; SREBP1; bHLHd1
• Reactivity: Human, Mouse, Rat
• Synonyms: SREBP-1; Polyclonal Antibody; SREBP-1 (Acetyl-Lys324) Polyclonal Antibody; SREBF1 BHLHD1 SREBP1; anti-SREBP-1 antibody

• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Form/Format: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
• Sequence Length: 1177

• Immunogen: Synthesized peptide derived from human SREBP-1 (Acetyl-Lys324)

Related Product Information for anti-SREBP-1 antibody

This antibody detects endogenous acetyl levels of SREBP-1 (Acetyl-Lys324) at Human:K324, Mouse:K318, Rat:K318

NCBI and Uniprot Product Information

• NCBI GI #: 52630419
• NCBI GeneID: 6720
• NCBI Accession #: NP_001005291.1
• NCBI GenBank Nucleotide #: NP_001005291.1
• UniProt Accession #: P36956
• NCBI Official Full Name: sterol regulatory element-binding protein 1 isoform a
• NCBI Official Synonym Full Names: sterol regulatory element binding transcription factor 1
• NCBI Official Symbol: SREBF1
• NCBI Official Synonym Symbols: SREBP1; bHLHd1
• NCBI Protein Information: sterol regulatory element-binding protein 1
• UniProt Protein Name: Sterol regulatory element-binding protein 1
• UniProt Gene Name: SREBF1
• UniProt Synonym Gene Names: BHLHD1; SREBP1; SREBP-1; bHLHd1
• UniProt Entry Name: SRBP1_HUMAN

NCBI Description

This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017]

Uniprot Description

SREBP-1: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle. Belongs to the SREBP family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: Golgi membrane; nucleoplasm; endoplasmic reticulum membrane; protein complex; endoplasmic reticulum; cytoplasm; integral to membrane; nuclear envelope; nucleus; cytosol

Molecular Function: protein dimerization activity; protein binding; sterol response element binding; DNA binding; sequence-specific DNA binding; protein complex binding; chromatin binding; transcription factor activity; protein kinase binding

Biological Process: response to food; response to drug; circadian rhythm; cholesterol metabolic process; response to glucagon stimulus; response to retinoic acid; response to cAMP; transcription, DNA-dependent; lipid biosynthetic process; positive regulation of cholesterol biosynthetic process; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; cellular response to starvation; negative regulation of insulin secretion; regulation of transcription from RNA polymerase II promoter; positive regulation of histone deacetylation; chemical signal regulation of heart rate; regulation of fatty acid metabolic process; response to glucose stimulus; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; lipid metabolic process; response to progesterone stimulus; lung development; aging