Rabbit anti-Zebrafish SREBF2 Polyclonal Antibody | anti-SREBF2 antibody
SREBF2 (Center) (DANRE) Rabbit pAb
NCBI and Uniprot Product Information
Uniprot Description
Function: Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes
By similarity. UniProtKB Q12772
Subunit structure: Forms a tight complex with scap in the ER membrane
By similarity. UniProtKB Q12772
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
By similarity. Golgi apparatus membrane; Multi-pass membrane protein
By similarity. Cytoplasmic vesicle › COPII-coated vesicle membrane; Multi-pass membrane protein
By similarity. Note: Moves from the endoplasmic reticulum to the Golgi in the absence of sterols
By similarity. UniProtKB Q12772Processed sterol regulatory element-binding protein 2: Nucleus
By similarity UniProtKB Q12772.
Post-translational modification: At low cholesterol the scap/srebp complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane
By similarity. UniProtKB Q12772
Sequence similarities: Belongs to the SREBP family.Contains 1 bHLH (basic helix-loop-helix) domain.
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Product Notes
The SREBF2 srebf2 (Catalog #AAA8556063) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SREBF2 (Center) (DANRE) Rabbit pAb reacts with Zebrafish and may cross-react with other species as described in the data sheet. AAA Biotech's SREBF2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:1000. Researchers should empirically determine the suitability of the SREBF2 srebf2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SREBF2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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