Rabbit anti-Human SPTLC2 Polyclonal Antibody | anti-SPTLC2 antibody

SPTLC2, ID (SPTLC2, KIAA0526, LCB2, Serine palmitoyltransferase 2, Long chain base biosynthesis protein 2, Long chain base biosynthesis protein 2a, Serine-palmitoyl-CoA transferase 2) (AP)

Cat. Num. AAA6350938

• Gene Names: SPTLC2; LCB2; SPT2; HSN1C; LCB2A; NSAN1C; hLCB2a
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SPTLC2; Polyclonal Antibody; ID (SPTLC2; KIAA0526; LCB2; Serine palmitoyltransferase 2; Long chain base biosynthesis protein 2; Long chain base biosynthesis protein 2a; Serine-palmitoyl-CoA transferase 2) (AP); Serine-palmitoyl-CoA transferase 2; anti-SPTLC2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-SPTLC2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: SPTLC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 372-401 amino acids from the Central region of human SPTLC2.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(SPTLC2 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SPTLC2 antibody detected the SPTLC2 protein (arrow).)

Related Product Information for anti-SPTLC2 antibody

This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. Alternatively spliced variants encoding different isoforms have been identified.

Product Categories/Family for anti-SPTLC2 antibody

Antibodies; KIAA; orf

References

Rotthier, A., et al. Am. J. Hum. Genet. 87(4):513-522(2010). Han, G., et al. Proc. Natl. Acad. Sci. U.S.A. 106(20):8186-8191(2009). Hornemann, T., et al. Biochem. J. 405(1):157-164(2007). Chen, M., et al. Plant Cell 18(12):3576-3593(2006). Olsen, J.V., et al. Cell 127(3):635-648(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 4758668
• NCBI GeneID: 9517
• NCBI Accession #: NP_004854.1
• NCBI GenBank Nucleotide #: NM_004863.3
• UniProt Accession #: O15270; Q16685
• Molecular Weight: 62,924 Da
• NCBI Official Full Name: serine palmitoyltransferase 2
• NCBI Official Synonym Full Names: serine palmitoyltransferase, long chain base subunit 2
• NCBI Official Symbol: SPTLC2
• NCBI Official Synonym Symbols: LCB2; SPT2; HSN1C; LCB2A; NSAN1C; hLCB2a
• NCBI Protein Information: serine palmitoyltransferase 2; LCB 2; SPT 2; serine-palmitoyl-CoA transferase 2; long chain base biosynthesis protein 2a; serine palmitoyltransferase, subunit II
• UniProt Protein Name: Serine palmitoyltransferase 2
• Protein Family: Serine palmitoyltransferase
• UniProt Gene Name: SPTLC2
• UniProt Synonym Gene Names: KIAA0526; LCB2; LCB 2; LCB2a; SPT 2
• UniProt Entry Name: SPTC2_HUMAN