Western Blot (WB)
(Western Blot analysis of extracts of various cell lines, using SPRR3 antibody.)
Rabbit anti-Mouse, Rat SPRR3 Polyclonal Antibody | anti-SPRR3 antibody
SPRR3 Polyclonal Antibody
Reactivity
Mouse, Rat
Applications
Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
SPRR3; Polyclonal Antibody; SPRR3 Polyclonal Antibody; Small proline-rich protein 3; 22 kDa pancornulin; Cornifin beta; Esophagin; SPRC; anti-SPRR3 antibody
Host
Rabbit
Reactivity
Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
SPRR3 polyclonal antibody detects endogenous levels of SPRR3 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
169
Applicable Applications for anti-SPRR3 antibody
Western Blot (WB)
Application Notes
WB: 1:500-1:1000
Immunogen
Recombinant protein of human SPRR3
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Western Blot (WB)
(Western Blot analysis of extracts of various cell lines, using SPRR3 antibody.)
Western Blot (WB)
(Western Blot analysis of extracts of various cell lines, using SPRR3 antibody.)
Related Product Information for anti-SPRR3 antibody
Esophagin, also known as small proline rich protein 3 (SPR3) or cornifin beta, belongs to the cornifin family of cornified-envelope structural proteins. It is expressed in mucosal epithelia such as esophagus and tongue and is strongly induced during epidermal keratinocyte differentiation. Due to its highly inducible nature, Esophagin is considered a marker of squamous differentiation. Esophagin serves as a cross-linking protein within the cornified cell envelope and may play a role in the maintenance of normal esophageal epithelial homeostasis. It shares significant homology with the related proteins, SPRR1 and SPRR2. Esophagin is typically not expressed in healthy human epithelium, but its expression is upregulated in numerous hyperproliferative disorders of the skin. In contrast, its expression is dramatically downregulated in esophageal squamous cell carcinoma
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~ 26kDa
NCBI Official Full Name
small proline-rich protein 3
NCBI Official Synonym Full Names
small proline rich protein 3
NCBI Official Symbol
SPRR3
NCBI Protein Information
small proline-rich protein 3
UniProt Protein Name
Small proline-rich protein 3
Protein Family
UniProt Gene Name
SPRR3
UniProt Synonym Gene Names
SPRC
UniProt Entry Name
SPRR3_HUMAN
Uniprot Description
SPRR3: Cross-linked envelope protein of keratinocytes. Belongs to the cornifin (SPRR) family.
Chromosomal Location of Human Ortholog: 1q21-q22
Cellular Component: cytoplasm
Molecular Function: protein binding; structural molecule activity
Biological Process: keratinocyte differentiation; epidermis development; wound healing; keratinization; peptide cross-linking
Research Articles on SPRR3
Similar Products
Product Notes
The SPRR3 sprr3 (Catalog #AAA3009652) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SPRR3 Polyclonal Antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SPRR3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:1000. Researchers should empirically determine the suitability of the SPRR3 sprr3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SPRR3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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