Western Blot (WB)
(SPRED3 Antibody (N-term) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the SPRED3 antibody detected the SPRED3 protein (arrow).)
Rabbit anti-Human, mouse SPRED3 Polyclonal Antibody | anti-SPRED3 antibody
SPRED3 Antibody (N-term)
Western Blot (WB)
(SPRED3 Antibody (N-term) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the SPRED3 antibody detected the SPRED3 protein (arrow).)
Western Blot (WB)
(SPRED3 Antibody (N-term) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the SPRED3 antibody detected the SPRED3 protein (arrow).)
Immunohistochemistry (IHC)
(SPRED3 antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of the SPRED3 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(SPRED3 antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of the SPRED3 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
602465)/SPRED family of proteins that regulate growth
factor-induced activation of the MAP kinase cascade (see MAPK1; MIM
176948) (Nonami et al., 2004 [PubMed 15465815]).
Nonami, A., et al. J. Biol. Chem. 279(50):52543-52551(2004)
Mizoguchi, M., et al. Neurogenetics 5(1):81-82(2004)
Kato, R., et al. Biochem. Biophys. Res. Commun. 302(4):767-772(2003)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein with a C-terminal Sprouty-like cysteine-rich domain (SRY) and an N-terminal Ena/Vasodilator-stimulated phosphoprotein (VASP) homology-1 (EVH-1) domain. The encoded protein is a member of a family of proteins that negatively regulates mitogen-activated protein (MAP) kinase signaling, particularly during organogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Uniprot Description
SPRED3: Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 19q13
Cellular Component: plasma membrane
Biological Process: multicellular organismal development; inactivation of MAPK activity
Research Articles on SPRED3
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Product Notes
The SPRED3 spred3 (Catalog #AAA9202504) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 31-59. The SPRED3 Antibody (N-term) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SPRED3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the SPRED3 spred3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SPRED3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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