Western Blot (WB)
(Western blot analysis of extracts of THP-1 cell line, using SPN antibody.)
Rabbit anti-Human SPN Polyclonal Antibody | anti-SPN antibody
SPN Polyclonal Antibody
Western Blot (WB)
(Western blot analysis of extracts of THP-1 cell line, using SPN antibody.)
Western Blot (WB)
(Western blot analysis of extracts of THP-1 cell line, using SPN antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a zinc finger domain-containing protein that functions as a regulator of transcription. The encoded proteins binds to its own promoter as well as to that of several target genes. Activity of this protein is important in the regulation of embryonic development. Mutations in this gene have been found in individuals with autosomal dominant mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Uniprot Description
DEAF1: a transcription factor that binds to its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE). Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase.
Protein type: Transcription, coactivator/corepressor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: cytoplasm; extracellular region; nucleolus; nucleoplasm; nucleus; transcription factor complex
Molecular Function: DNA binding; metal ion binding; protein binding; transcription factor activity
Biological Process: anatomical structure morphogenesis; behavioral fear response; embryonic skeletal development; germ cell development; negative regulation of transcription, DNA-dependent; neural tube closure; positive regulation of transcription, DNA-dependent; regulation of mammary gland epithelial cell proliferation; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; visual learning
Disease: Mental Retardation, Autosomal Dominant 24
Research Articles on SPN
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Product Notes
The SPN deaf1 (Catalog #AAA2535287) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SPN Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SPN can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500-1:2000, IHC: 1:50-1:200. Researchers should empirically determine the suitability of the SPN deaf1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SPN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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