Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using SPINLW1 antibody.)
Rabbit anti-Human SPINLW1 Polyclonal Antibody | anti-SPINLW1 antibody
SPINLW1 (Serine Protease Inhibitor-like with Kunitz and WAP Domains 1, Epididymal Protease Inhibitor, EPPIN, EPPIN1, EPPIN2, EPPIN3, WAP7, WFDC7, dJ461P17.2,CT71, CT72, SPINLW1) (HRP)
WB: 1:500-1:2000
IHC: 1:50-1:200
Applications are based on unconjugated antibody.
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using SPINLW1 antibody.)
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using SPINLW1 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human esophagus using SPINLW1 antibody at dilution of 1:200 (400x lens).)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human esophagus using SPINLW1 antibody at dilution of 1:200 (400x lens).)
Immunofluorescence (IF)
(Immunofluorescence analysis of HepG2 cell using SPINLW1 antibody. Blue: DAPI for nuclear staining.)
Immunofluorescence (IF)
(Immunofluorescence analysis of HepG2 cell using SPINLW1 antibody. Blue: DAPI for nuclear staining.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility and exhibits antimicrobial activity against E. coli, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Uniprot Description
Spinlw1: Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Inhibitor; Secreted; Secreted, signal peptide; Cancer Testis Antigen (CTA)
Chromosomal Location of Human Ortholog: 20q13.12
Cellular Component: cell surface; extracellular region
Molecular Function: serine-type endopeptidase inhibitor activity; protein binding
Biological Process: defense response to bacterium; negative regulation of peptidase activity
Research Articles on SPINLW1
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Product Notes
The SPINLW1 eppin (Catalog #AAA6438732) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SPINLW1 (Serine Protease Inhibitor-like with Kunitz and WAP Domains 1, Epididymal Protease Inhibitor, EPPIN, EPPIN1, EPPIN2, EPPIN3, WAP7, WFDC7, dJ461P17.2,CT71, CT72, SPINLW1) (HRP) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SPINLW1 can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC). IF: 1:50-1:200 WB: 1:500-1:2000 IHC: 1:50-1:200 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the SPINLW1 eppin for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SPINLW1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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