Testing Data
(Sample(30 ug of whole cell lysate)A: HeLa S3 12% SDS PAGEPrimary antibody diluted at 1: 500)
Rabbit anti-Human SPFH2 Polyclonal Antibody | anti-SPFH2 antibody
SPFH2 antibody
Immunohistochemistry: 1:100-1:250
Testing Data
(Sample(30 ug of whole cell lysate)A: HeLa S3 12% SDS PAGEPrimary antibody diluted at 1: 500)
Testing Data
(Sample(30 ug of whole cell lysate)A: HeLa S3 12% SDS PAGEPrimary antibody diluted at 1: 500)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded endo mitral OVCA, using ERLIN2 antibody at 1: 100 dilution.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded endo mitral OVCA, using ERLIN2 antibody at 1: 100 dilution.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Uniprot Description
SPFH2: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway. Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination. Forms a heteromeric complex with ERLIN1. Ubiquitous. Belongs to the band 7/mec-2 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Endoplasmic reticulum; Membrane protein, integral
Chromosomal Location of Human Ortholog: 8p11.2
Cellular Component: endoplasmic reticulum membrane; protein complex; endoplasmic reticulum; cytoplasm; plasma membrane; integral to membrane
Molecular Function: protein binding
Biological Process: ER-associated protein catabolic process
Disease: Spastic Paraplegia 18, Autosomal Recessive
Research Articles on SPFH2
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Product Notes
The SPFH2 erlin2 (Catalog #AAA9410695) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SPFH2 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SPFH2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western blotting: 1:500-1:3000 Immunohistochemistry: 1:100-1:250. Researchers should empirically determine the suitability of the SPFH2 erlin2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SPFH2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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