Rabbit anti-Human Spectrin Beta 3 Polyclonal Antibody | anti-Sptbn2 antibody

Spectrin Beta 3 (Beta III Spectrin, KIAA0302, Spectrin beta Chain Brain 2, Spectrin beta Non-erythrocytic 2, Spectrin Non-erythroid beta Chain 2, SPTBN2, Spinocerebellar Ataxia 5, SCA5, SCA 5)

Cat. Num. AAA622101

• Gene Names: Sptbn2; Spnb3
• Reactivity: Human
• Applications: Immunoprecipitation, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Spectrin Beta 3; Polyclonal Antibody; Spectrin Beta 3 (Beta III Spectrin; KIAA0302; Spectrin beta Chain Brain 2; Spectrin beta Non-erythrocytic 2; Spectrin Non-erythroid beta Chain 2; SPTBN2; Spinocerebellar Ataxia 5; SCA5; SCA 5); Anti -Spectrin Beta 3 (Beta III Spectrin; anti-Sptbn2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Species Crossreactivity: This antibody reacts with human. Other species have not been tested.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Tris-citrate/phosphate buffer, pH 7 to 8

• Applicable Applications for anti-Sptbn2 antibody: Immunoprecipitation (IP), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Immunoprecipitation and Immunohistochemistry.
• Immunogen: The epitope recognized by this antibody maps to a region between residues 2150 and 2200 of human spectrin, beta, non-erythrocytic 2 (spinocerebellar ataxia 5) using the numbering given in entry NP_008877.1. Homology: 100% with human, mouse, and rat protein.
• Positive Control: HeLa whole cell lysate
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-Sptbn2 antibody

Mutations in spectrins are a previously unknown cause of ataxia and neurodegenerative disease that affect membrane proteins involved in glutamate signaling. Spectrin-beta IIIs have been recognized as ataxia disease genes and their mutations cause spinocerebellar ataxia type 5 (SCA5).

Product Categories/Family for anti-Sptbn2 antibody

Antibodies; Abs to Spectrin

NCBI and Uniprot Product Information

• NCBI GI #: 9507135
• NCBI GeneID: 29211
• NCBI Accession #: NP_062040.1
• NCBI GenBank Nucleotide #: NM_019167.1
• UniProt Accession #: Q9QWN8; O88197; Q9ES68
• Molecular Weight: 271,064 Da
• NCBI Official Full Name: spectrin beta chain, non-erythrocytic 2
• NCBI Official Synonym Full Names: spectrin, beta, non-erythrocytic 2
• NCBI Official Symbol: Sptbn2
• NCBI Official Synonym Symbols: Spnb3
• NCBI Protein Information: spectrin beta chain, non-erythrocytic 2; SPNB-3; beta-spectrin 3; spectrin beta 3; beta-III spectrin; beta SpIII sigma 1; spectrin beta chain, brain 2; spectrin-like protein GTRAP41; spectrin, non-erythroid beta chain 2; glutamate transporter EAAT4-associated protein 41
• UniProt Protein Name: Spectrin beta chain, non-erythrocytic 2
• Protein Family: Spectrin
• UniProt Gene Name: Sptbn2
• UniProt Synonym Gene Names: Spnb3
• UniProt Entry Name: SPTN2_RAT

NCBI Description

may modulate the structural integrity of the Golgi apparatus; binds preferentially to Arp1 rather than actin to mediate the direct interaction of dynein and dynactin with vesicles [RGD, Feb 2006]

Uniprot Description

SPTBN2: Probably plays an important role in neuronal membrane skeleton. Defects in SPTBN2 are the cause of spinocerebellar ataxia type 5 (SCA5). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA5 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder with variable age at onset, ranging between 10 and 50 years. Belongs to the spectrin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Cellular Component: spectrin; extracellular space; nuclear matrix; cell soma; apical plasma membrane; cytoplasm; cytosol; cell junction

Molecular Function: structural constituent of cytoskeleton; phospholipid binding; actin binding

Biological Process: vesicle-mediated transport; synaptic vesicle exocytosis; synaptogenesis; actin filament capping; adult behavior; multicellular organism growth; cerebellar Purkinje cell layer morphogenesis; regulation of calcium ion-dependent exocytosis; synaptic vesicle docking during exocytosis