Rabbit SOX4 Polyclonal Antibody | anti-SOX4 antibody

SOX4 Polyclonal Antibody

Cat. Num. AAA3015209

• Gene Names: SOX4; EVI16
• Reactivity: Human, Mouse, Rat, Chicken
• Applications: Western Blot
• Purity: affinity purified by Protein A
• Synonyms: SOX4; Polyclonal Antibody; SOX4 Polyclonal Antibody; SOX 4; SOX-4; Ecotropic viral integration site 16; EVI 16; EVI16; SRY (sex determining region Y) box 4; SRY box containing gene 4; SRY related HMG box gene 4; SOX4_HUMAN.; anti-SOX4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat, Chicken
• Clonality: Polyclonal
• Specificity: SOX4 Polyclonal Antibody detects endogenous levels of SOX4 protein.
• Purity/Purification: affinity purified by Protein A
• Form/Format: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Applicable Applications for anti-SOX4 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-2000
• Immunogen: KLH conjugated synthetic peptide derived from human SOX4
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Testing Data

Related Product Information for anti-SOX4 antibody

Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.

NCBI and Uniprot Product Information

• NCBI GI #: 4507163
• NCBI GeneID: 6659
• NCBI Accession #: NP_003098
• NCBI GenBank Nucleotide #: NM_003107.2
• UniProt Accession #: Q06945
• Molecular Weight: Predicted: 52 kDa; ; Observed: 520 kDa
• NCBI Official Full Name: transcription factor SOX-4
• NCBI Official Synonym Full Names: SRY (sex determining region Y)-box 4
• NCBI Official Symbol: SOX4
• NCBI Official Synonym Symbols: EVI16
• NCBI Protein Information: transcription factor SOX-4; SRY-related HMG-box gene 4; ecotropic viral integration site 16
• UniProt Protein Name: Transcription factor SOX-4
• Protein Family: Transcription factor
• UniProt Gene Name: SOX4
• UniProt Entry Name: SOX4_HUMAN

NCBI Description

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008]

Uniprot Description

SOX4: Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 6p22.3

Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleus

Molecular Function: protein binding; protein heterodimerization activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; negative regulation of protein export from nucleus; positive regulation of translation; somatic stem cell maintenance; positive regulation of apoptosis; heart development; positive regulation of transcription, DNA-dependent; regulation of protein stability; Wnt receptor signaling pathway through beta-catenin; glucose homeostasis; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; glial cell proliferation; negative regulation of cell proliferation; sympathetic nervous system development; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of Wnt receptor signaling pathway; skeletal development; T cell differentiation; glial cell development; pro-B cell differentiation; protein stabilization; positive regulation of insulin secretion; DNA damage response, detection of DNA damage; spinal cord motor neuron differentiation; endocrine pancreas development; limb bud formation; spinal cord development; negative regulation of protein ubiquitination; positive regulation of transcription from RNA polymerase II promoter; neural tube formation