Rabbit SOS2 Polyclonal Antibody | anti-SOS2 antibody

SOS2 (Son of sevenless Homolog 2, SOS-2) (HRP)

Cat. Num. AAA6450331

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunocytochemistry
• Purity: Purified by Immunoaffinity chromatography.
• Synonyms: SOS2; Polyclonal Antibody; SOS2 (Son of sevenless Homolog 2; SOS-2) (HRP); Son of sevenless Homolog 2; SOS-2; anti-SOS2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes endogenous levels of human SOS2. Species Crossreactivity: mouse and rat
• Purity/Purification: Purified by Immunoaffinity chromatography.
• Form/Format: Supplied as a liquid PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-SOS2 antibody: Western Blot (WB), Immunocytochemistry (ICC)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide corresponding to aa671-716 of human SOS2. UniProt Accession: Q07890.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-SOS2 antibody

The superfamily of GTP-binding proteins, of which Ras proteins are prototypes, has been implicated in a broad range of biological activities. Studies have identified a family of guanine nucleotide-releasing factors (GRFs) that activate Ras in mammalian cells and an "adapter" protein (Sem 5/GRB2) that appears to mediate the interaction of GRFs with activated receptor molecules. Ras-GRF p140 promotes nucleotide exchange on Ras p21s but not on other members of the Ras gene superfamily. In addition, three mammalian homologs of the Drosophila Ras-GRF, son of sevenless (Sos), have been described. These include two from mouse, mSos 1 and mSos 2, and one from human, hSos. Vav p95 has been reported to function as a GRF in activation of Ras by the T cell receptor and has been reported to have a domain similar to that of Dbl p115, which is a GRF specific for Cdc42Hs. Subsequent to activation, Ras appears to interact with Raf, thereby activating the MAP kinase phosphorylation pathway.

Product Categories/Family for anti-SOS2 antibody

Antibodies; GTPase; Rab; Ras; Rho Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 154689780
• NCBI GeneID: 6655
• NCBI Accession #: NP_008870.2
• NCBI GenBank Nucleotide #: NM_006939.2
• UniProt Accession #: Q07890; Q15503; Q17RN1; D3DSB4
• Molecular Weight: 152,979 Da
• NCBI Official Full Name: son of sevenless homolog 2
• NCBI Official Synonym Full Names: son of sevenless homolog 2 (Drosophila)
• NCBI Official Symbol: SOS2
• NCBI Protein Information: son of sevenless homolog 2; SOS-2; guanine nucleotide exchange factor; guanine nucleotide releasing factor
• UniProt Protein Name: Son of sevenless homolog 2
• Protein Family: Son of sevenless
• UniProt Gene Name: SOS2
• UniProt Synonym Gene Names: SOS-2
• UniProt Entry Name: SOS2_HUMAN

Uniprot Description

SOS2: a guanine nucleotide exchange factor that activates Ras by catalyzing the exchange of bound GDP for GTP. Interacts with GRB2.

Protein type: Motility/polarity/chemotaxis; GEFs, Ras; GEFs; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 14q21

Cellular Component: cytosol

Molecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; DNA binding; protein heterodimerization activity

Biological Process: positive regulation of small GTPase mediated signal transduction; axon guidance; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction