Testing Data
Rabbit anti-Human Sos1 Polyclonal Antibody | anti-Sos1 antibody
Anti-Sos1 Antibody
Testing Data
Testing Data
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]
Uniprot Description
SOS1: a guanine nucleotide exchange factor that activates Ras by catalyzing the exchange of bound GDP for GTP. Interacts with GRB2, NCK, and other adapter proteins. Plays an important role in signaling pathways leading from the G-protein- coupled receptors and receptor tyrosine kinases to MAPK/ERK.
Protein type: Adaptor/scaffold; GEFs; GEFs, Ras; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2p21
Cellular Component: cell soma; postsynaptic density; plasma membrane; cytosol
Molecular Function: protein binding; Rho guanyl-nucleotide exchange factor activity; DNA binding; protein heterodimerization activity; SH3 domain binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: epidermal growth factor receptor signaling pathway; platelet activation; axon guidance; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; signal transduction; positive regulation of small GTPase mediated signal transduction; regulation of small GTPase mediated signal transduction; positive regulation of epidermal growth factor receptor signaling pathway; small GTPase mediated signal transduction; Ras protein signal transduction; insulin receptor signaling pathway; innate immune response; blood coagulation; leukocyte migration
Disease: Fibromatosis, Gingival, 1; Noonan Syndrome 4
Research Articles on Sos1
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Product Notes
The Sos1 sos1 (Catalog #AAA415440) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Sos1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Sos1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Optimal dilutions to be determined by researchers. Researchers should empirically determine the suitability of the Sos1 sos1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Sos1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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