Western Blot (WB)
(Western Blot: Sample: Lane1: Human HepG2 Cells; Lane2: Porcine Brain Tissue.)
Rabbit anti-Human Sortilin 1 Polyclonal Antibody | anti-SORT1 antibody
Polyclonal Antibody to Sortilin 1 (SORT1)
Immunohistochemistry: 5-20ug/mL;1:20-80
Immunocytochemistry: 5-20ug/mL;1:20-80
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Lane1: Human HepG2 Cells; Lane2: Porcine Brain Tissue.)
Western Blot (WB)
(Western Blot: Sample: Lane1: Human HepG2 Cells; Lane2: Porcine Brain Tissue.)
Western Blot (WB)
(Western Blot: Sample: Recombinant SORT1, Human.)
Western Blot (WB)
(Western Blot: Sample: Recombinant SORT1, Human.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P. Samples: Human Tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P. Samples: Human Tissue))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the VPS10-related sortilin family of proteins. The encoded preproprotein is proteolytically processed by furin to generate the mature receptor. This receptor plays a role in the trafficking of different proteins to either the cell surface, or subcellular compartments such as lysosomes and endosomes. Expression levels of this gene may influence the risk of myocardial infarction in human patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Uniprot Description
SORT1: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. A common polymorphism located in a non-coding region between CELSR2 and PSRC1 alters a CEBP transcription factor binding site and is responsible for changes in hepatic expression of SORT1. Altered SORT1 expression in liver affects low density lipoprotein cholesterol levels in plasma and is associated with susceptibility to myocardial infarction. Belongs to the VPS10-related sortilin family. SORT1 subfamily.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1p13.3|1p21.3-p13.1
Cellular Component: cell soma; cell surface; clathrin-coated pit; clathrin-coated vesicle; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; dendrite; early endosome; endoplasmic reticulum membrane; endosome membrane; Golgi apparatus; integral component of membrane; lysosomal membrane; nuclear membrane; perinuclear region of cytoplasm; plasma membrane; trans-Golgi network transport vesicle
Molecular Function: enzyme binding; nerve growth factor binding; nerve growth factor receptor activity; neurotensin receptor activity, non-G-protein coupled; protein binding
Biological Process: endocytosis; endosome to lysosome transport; endosome transport via multivesicular body sorting pathway; G-protein coupled receptor signaling pathway; glucose import; Golgi to endosome transport; induction of apoptosis via death domain receptors; multicellular organism development; myotube differentiation; negative regulation of fat cell differentiation; negative regulation of lipoprotein lipase activity; nerve growth factor receptor signaling pathway; neuropeptide signaling pathway; ossification; plasma membrane to endosome transport; regulation of gene expression; response to insulin stimulus; vesicle organization and biogenesis
Disease: Low Density Lipoprotein Cholesterol Level Quantitative Trait Locus 6
Research Articles on SORT1
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Product Notes
The SORT1 sort1 (Catalog #AAA2026243) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Sortilin 1 (SORT1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Sortilin 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.5-2ug/mL;1:200-800 Immunohistochemistry: 5-20ug/mL;1:20-80 Immunocytochemistry: 5-20ug/mL;1:20-80 Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the SORT1 sort1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Sortilin 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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