Rabbit anti-Human SORL1 Polyclonal Antibody | anti-SORL1 antibody
SORL1 Polyclonal Antibody
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease. [provided by RefSeq, Feb 2016]
Uniprot Description
SORL1: Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction. Belongs to the VPS10-related sortilin family. SORL1 subfamily.
Protein type: Cell surface; Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q23.2-q24.2
Cellular Component: Golgi apparatus; extracellular space; Golgi cisterna; integral to plasma membrane; endoplasmic reticulum; early endosome; trans-Golgi network; multivesicular body; recycling endosome; cell soma; membrane; nuclear envelope lumen; endosome
Molecular Function: ADP-ribosylation factor binding; protein binding; transmembrane receptor activity; beta-amyloid binding; low-density lipoprotein binding
Biological Process: cholesterol metabolic process; negative regulation of MAP kinase activity; receptor-mediated endocytosis; protein targeting to lysosome; cell migration; protein maturation; lipid transport; signal transduction; negative regulation of neurogenesis; negative regulation of protein oligomerization; cell proliferation; regulation of smooth muscle cell migration; positive regulation of protein catabolic process; post-Golgi vesicle-mediated transport; protein targeting to Golgi; negative regulation of protein binding; protein retention in Golgi; protein targeting
Disease: Alzheimer Disease
Research Articles on SORL1
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Product Notes
The SORL1 sorl1 (Catalog #AAA8567787) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SORL1 Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SORL1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the SORL1 sorl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SORL1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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