Goat SORD/Sorbitol Dehydrogenase Polyclonal Antibody | anti-SORD antibody

Anti-SORD/Sorbitol Dehydrogenase Antibody (aa345-357)

Cat. Num. AAA2400867

• Gene Names: SORD; SORD1; HEL-S-95n
• Reactivity: Human; Predicted: Mouse
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: SORD/Sorbitol Dehydrogenase; Polyclonal Antibody; Anti-SORD/Sorbitol Dehydrogenase Antibody (aa345-357); Mouse Monoclonal [clone 9E7] (IgG2a) to Human SORD/Sorbitol Dehydrogenase; SORD; L-iditol 2-dehydrogenase; SORD1; Sorbitol dehydrogenase; anti-SORD antibody

• Host: Goat
• Reactivity: Human; Predicted: Mouse
• Clonality: Polyclonal
• Specificity: Human SORD.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Sequence Length: 357

• Applicable Applications for anti-SORD antibody: ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
• Application Notes: ELISA: 1:64000; IHC-P: 5 ug/ml; WB: 1:64000, 0.1-1 ug/ml
• Immunogen: Synthetic peptide KIMLKCDPSDQNP from the C-terminus of human SORD (NP_003095.2). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (92%), Orangutan (92%), Gibbon (92%), Monkey (92%), Rabbit (92%), Chicken (92%), Platypus (92%), Marmoset (85%), Sheep (85%), Hamster (85%), Elephant (85%), Panda (85%), Dog (85%), Horse (85%), Opossum (85%), Turkey (85%), Salmon (85%).
• Conjugation: Unconjugated
• Epitope: aa345-357
• Preparation and Storage: Store at -20 degree C.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Anti-SORD antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Western Blot (WB)

(Antibody (0.1 ug/ml) staining of Mouse Kidney lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)

Related Product Information for anti-SORD antibody

Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and togetherwith aldose reductase (ALDR1; MIM 103880), makes up the sorbitolpathway that is believed to play an important role in the development ofdiabetic complications (summarized by Carr and Markham, 1995 [PubMed8535074]). the first reaction of the pathway (also called the polyolpathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH asthe cofactor.

NCBI and Uniprot Product Information

• NCBI GI #: 156627571
• NCBI GeneID: 6652
• NCBI Accession #: NP_003095.2
• NCBI GenBank Nucleotide #: NM_003104.5
• UniProt Accession #: Q00796; Q16682; Q9UMD6; B2R655; B7Z3A6; J3JZZ5
• Molecular Weight: 10,812 Da
• NCBI Official Full Name: sorbitol dehydrogenase
• NCBI Official Synonym Full Names: sorbitol dehydrogenase
• NCBI Official Symbol: SORD
• NCBI Official Synonym Symbols: SORD1; HEL-S-95n
• NCBI Protein Information: sorbitol dehydrogenase
• UniProt Protein Name: Sorbitol dehydrogenase
• Protein Family: Sorbitol-6-phosphate 2-dehydrogenase
• UniProt Gene Name: SORD

NCBI Description

Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]

Uniprot Description

Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm.