Rabbit anti-Human SORBS3 Polyclonal Antibody | anti-SORBS3 antibody

SORBS3 Antibody, FITC conjugated

Cat. Num. AAA1494430

• Gene Names: SORBS3; SCAM1; SH3D4; SCAM-1
• Reactivity: Human
• Applications: ELISA
• Purity: >95%, Protein G Purified
• Synonyms: SORBS3; Polyclonal Antibody; SORBS3 Antibody; FITC conjugated; Vinexin; SCAM1; SH3-containing adapter molecule 1; SCAM-1; Sorbin and SH3 domain-containing protein 3; anti-SORBS3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G Purified
• Sequence Length: 329

• Applicable Applications for anti-SORBS3 antibody: ELISA (EIA)
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: FITC
• Immunogen: Recombinant human Vinexin protein
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-14145 / sc-14146 / sc-14144
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-SORBS3 antibody

Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.

NCBI and Uniprot Product Information

• NCBI GI #: 65301112
• NCBI GeneID: 10174
• NCBI Accession #: NP_001018003.1
• NCBI GenBank Nucleotide #: NM_001018003.2
• UniProt Accession #: O60504; Q5BJE4; Q6NX54; Q96FY4; Q9UQE4
• Molecular Weight: 36,742 Da
• NCBI Official Full Name: vinexin isoform 2
• NCBI Official Synonym Full Names: sorbin and SH3 domain containing 3
• NCBI Official Symbol: SORBS3
• NCBI Official Synonym Symbols: SCAM1; SH3D4; SCAM-1
• NCBI Protein Information: vinexin
• UniProt Protein Name: Vinexin
• Protein Family: Vinexin
• UniProt Gene Name: SORBS3
• UniProt Synonym Gene Names: SCAM1; SCAM-1
• UniProt Entry Name: VINEX_HUMAN

NCBI Description

This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Description

vinexin: an adapter protein that contains three SH3 domains and is involved in the reorganization of actin cytoskeleton. Two alternatively spliced isoforms have been described. Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain. Both isoforms localize at focal adhesion and cell-cell adhesion sites; vinexin beta was also found in the nucleus. Interacts with DLG5 through its third SH3 domain. Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC) through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with SAFB2.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Cell adhesion; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 8p21.3

Cellular Component: cytoskeleton; cytosol; focal adhesion; nucleus

Molecular Function: protein binding; structural constituent of cytoskeleton; transcription factor binding; vinculin binding

Biological Process: actin filament organization; cell adhesion; cell-substrate adhesion; muscle contraction; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cytoskeleton organization and biogenesis; positive regulation of MAPKKK cascade; positive regulation of stress fiber formation