Goat anti-Human Solute carrier family 26, member 5 Polyclonal Antibody | anti-SLC26A6 antibody

Solute carrier family 26, member 5 (SLC26A5, Prestin DFNB61, MGC118886, MGC118887, MGC118888, MGC118889, PRES)

Cat. Num. AAA625886

• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified; Purified by affinity chromatography.
• Synonyms: Solute carrier family 26; member 5; Polyclonal Antibody; member 5 (SLC26A5; Prestin DFNB61; MGC118886; MGC118887; MGC118888; MGC118889; PRES); Anti -Solute carrier family 26; anti-SLC26A6 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SLC26A5.
• Purity/Purification: Affinity Purified; Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-SLC26A6 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: ELISA: 1:32,000
• Immunogen: Synthetic peptide, ERLHTKDKVPDSIAD, from the N-Terminus (near) of human SLC26A5.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 monthsat -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-SLC26A6 antibody

This gene is a member of the SLC26A/SulP transporter family. It encodes a protein that is specifically expressed in outer hair cells (OHCs) of the cochlea and is essential in auditory processing. Intracellular anions are thought to act as extrinsic voltage sensors, which bind to this protein and trigger the conformational changes required for rapid length changes in OHCs. Mutations in this gene have been associated with non-syndromic hearing loss. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Product Categories/Family for anti-SLC26A6 antibody

Antibodies; Abs to Ion Transport

NCBI and Uniprot Product Information

• NCBI GI #: 528524502
• NCBI GeneID: 65010
• NCBI Accession #: NP_001268661.1
• NCBI GenBank Nucleotide #: NM_001281732.1
• UniProt Accession #: Q9BXS9; Q548A7; Q96Q90; Q9NQU1
• Molecular Weight: 82,967 Da
• NCBI Official Full Name: solute carrier family 26 member 6 isoform 5
• NCBI Official Synonym Full Names: solute carrier family 26 (anion exchanger), member 6
• NCBI Official Symbol: SLC26A6
• NCBI Protein Information: solute carrier family 26 member 6; pendrin L1; anion transporter 1; sulfate anion transporter; anion exchange transporter; solute carrier family 26, member 6
• UniProt Protein Name: Solute carrier family 26 member 6
• Protein Family: Solute carrier family
• UniProt Gene Name: SLC26A6
• UniProt Synonym Gene Names: Pendrin-L1
• UniProt Entry Name: S26A6_HUMAN

NCBI Description

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2013]

Uniprot Description

SLC26A6: Does not seem to be involved in anion transport. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter; Transporter, SLC family; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: cytoplasmic vesicle membrane; membrane; integral to plasma membrane; brush border membrane; endoplasmic reticulum; basolateral plasma membrane; apical plasma membrane; plasma membrane; integral to membrane; vesicle membrane

Molecular Function: formate transmembrane transporter activity; bicarbonate transmembrane transporter activity; chloride channel activity; formate efflux transmembrane transporter activity; anion:anion antiporter activity; oxalate transmembrane transporter activity; secondary active sulfate transmembrane transporter activity; PDZ domain binding; protein binding; formate uptake transmembrane transporter activity; efflux transmembrane transporter activity; chloride transmembrane transporter activity; sulfate transmembrane transporter activity

Biological Process: intracellular pH elevation; epithelial fluid transport; transepithelial chloride transport; mannitol transport; sulfate transport; chloride transport; oxalic acid secretion; intestinal absorption; bicarbonate transport; regulation of intracellular pH; ion transport; oxalate transport; transmembrane transport; sperm capacitation; formate transport