Rabbit anti-Human SOGA1 Polyclonal Antibody | anti-SOGA1 antibody

SOGA1 Antibody

Cat. Num. AAA153573

• Gene Names: SOGA1; SOGA; KIAA0889; C20orf117
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunofluorescence
• Purity: SOGA1 Antibody is affinity chromatography purified via peptide column.
• Synonyms: SOGA1; Polyclonal Antibody; SOGA1 Antibody; SOGA1 Antibody : SOGA; KIAA0889; C20orf117; SOGA; Protein SOGA1; SOGA family member 1; 80-kDa SOGA fragment; suppressor of glucose; autophagy associated 1; anti-SOGA1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: SOGA1 antibody is human specific. At least four isoforms of SOGA1 are known to exist.
• Purity/Purification: SOGA1 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 1016

• Applicable Applications for anti-SOGA1 antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
• Application Notes: SOGA1 antibody can be used for detection of SOGA1 by Western blot at 1 - 2 mug/ml.
• Conjugate: Unconjugated
• Immunogen: SOGA1 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human SOGA.
• Buffer: SOGA1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: SOGA1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.

Western Blot (WB)

(Western blot analysis of SOGA1 in Hela cell lysate with SOGA1 antibody at (A) 1 and (B) 2 μg/ml.)

Immunofluorescence (IF)

(Immunofluorescence of SOGA1 in HeLa cells with SOGA1 antibody at 5 μg/mL.)

Related Product Information for anti-SOGA1 antibody

The recently identified protein suppressor of glucose by autophagy protein 1 (SOGA1) has been found to be involved in the regulation of autophagy (1). SOGA1 is thought to contribute to adiponectin-mediated insulin-dependent inhibition of autophagy during the activation of adenosine monophosphate kinase (AMPK) (1,2). SOGA1 contains an internal signal peptide that enables the secretion of a circulating fragment of SOGA1, providing a surrogate marker for intracellular SOGA1 levels (2). Knockdown of SOGA1 elevated glucose production in primary hepatocytes indicates that SOGA1 is an inhibitor of glucose production. It thus might be useful as a novel therapeutic target for diabetes (3).

NCBI and Uniprot Product Information

• NCBI GI #: 66773344
• NCBI GeneID: 140710
• NCBI Accession #: NP_954650
• NCBI GenBank Nucleotide #: NM_199181.2
• UniProt Accession #: O94964; Q14DB2; Q5JW51; Q6ZTG8; A6NK10
• Molecular Weight: Predicted: 183 kDa; ; Observed: 200kDa
• NCBI Official Full Name: protein SOGA1 isoform 2
• NCBI Official Synonym Full Names: suppressor of glucose, autophagy associated 1
• NCBI Official Symbol: SOGA1
• NCBI Official Synonym Symbols: SOGA; KIAA0889; C20orf117
• NCBI Protein Information: protein SOGA1; SOGA family member 1; suppressor of glucose by autophagy; suppressor of glucose from autophagy; suppressor of glucose, autophagy-associated protein 1
• UniProt Protein Name: Protein SOGA1
• Protein Family: Protein
• UniProt Gene Name: SOGA1
• UniProt Synonym Gene Names: C20orf117; KIAA0889; SOGA; 80-kDa SOGA fragment
• UniProt Entry Name: SOGA1_HUMAN

Uniprot Description

SOGA1: Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner. Belongs to the SOGA family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Autophagy

Chromosomal Location of Human Ortholog: 20q11.23

Cellular Component: extracellular space

Biological Process: negative regulation of gluconeogenesis; insulin receptor signaling pathway; regulation of autophagy