Rabbit SODD Polyclonal Antibody | anti-SODD antibody

SODD Antibody

Cat. Num. AAA5311222

• Gene Names: BAG4; SODD; BAG-4
• Applications: Western Blot
• Purity: Affinity Chromatography
• Synonyms: SODD; Polyclonal Antibody; SODD Antibody; Rabbit Polyclonal SODD Antibody; Polyclonal SODD antibody; anti-SODD antibody; BAG-4 antibody; BAG family molecular chaperone regulator 4 antibody; Bcl-2-associated athanogene 4 antibody; Silencer of death domains antibody

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Chromatography
• Form/Format: Supplied in PBS buffer, pH 7.2, containing 50% Glycerol, 1% BSA, 0.02% Thimerosal
• Concentration: 500 ug/ml (varies by lot)
• Sequence Length: 457

• Applicable Applications for anti-SODD antibody: Western Blot (WB)
• Application Notes: WB: 1-2 ug/ml
• Immunogen: SODD antibody was raised in Rabbit using synthetic peptide mapping to the N-terminus of human SODD as the immunogen.
• Cross-Reactivity: Human, Mouse, Rat
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-SODD antibody

Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. Cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of these death receptors. A novel TNF-R1 interacting protein was recently identified and designated SODD for silencer of death domain. SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines.

Product Categories/Family for anti-SODD antibody

Cell Cycle & Cell Death

NCBI and Uniprot Product Information

• NCBI GI #: 4160014
• NCBI GeneID: 9530
• NCBI Official Full Name: silencer of death domains
• NCBI Official Synonym Full Names: BCL2 associated athanogene 4
• NCBI Official Symbol: BAG4
• NCBI Official Synonym Symbols: SODD; BAG-4
• NCBI Protein Information: BAG family molecular chaperone regulator 4
• Protein Family: Superoxide dismutase

NCBI Description

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]