Western Blot (WB)
(Western blot analysis of TRIM58 in (A) human heart tissue and (B) mouse kidney lysate with TRIM58 antibody at 1 μg/mL.)
Rabbit TRIM58 Polyclonal Antibody | anti-TRIM58 antibody
TRIM58 Antibody
Gene Names
TRIM58; BIA2
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot
Purity
Affinity chromatography purified via peptide column.
Synonyms
TRIM58; Polyclonal Antibody; TRIM58 Antibody; Tripartite motif containing 58 protein; BIA2; anti-TRIM58 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
486
Applicable Applications for anti-TRIM58 antibody
ELISA (EIA), Western Blot (WB)
Application Notes
Western blot at 1 - 2 mug/mL.
Conjugate
Unconjugated
Immunogen
TRIM58 antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human TRIM58.
Buffer
TRIM58 Antibody is supplied in PBS containing 0.02% sodium azide.
Species
Human
Preparation and Storage
Store at 4 degree C for three months and -20 degree C, stable for up to one year.
As with all antibodies care should be taken to avoid repeated freeze thaw cycles
Antibodies should not be exposed to prolonged high temperatures.
As with all antibodies care should be taken to avoid repeated freeze thaw cycles
Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of TRIM58 in (A) human heart tissue and (B) mouse kidney lysate with TRIM58 antibody at 1 μg/mL.)
Western Blot (WB)
(Western blot analysis of TRIM58 in (A) human heart tissue and (B) mouse kidney lysate with TRIM58 antibody at 1 μg/mL.)
Related Product Information for anti-TRIM58 antibody
TRIM58 Antibody: TRIM58 is a member of the tripartite motif-containing family of proteins that frequently possess E3 ubiquitin ligase activities (1). TRIM58 is strongly expressed in erythroid lineage cells and is further upregulated during late erythroid maturation. Recent experiments suggest that TRIM58 facilitates erythroblast enucleation by ubiquitinating the intermediate chain of the microtubule motor dynein, thereby inducing proteolytic degradation (2).
Product Categories/Family for anti-TRIM58 antibody
References
1. Napolitano LM and Meroni G. TRIM family: Pleiotropy and diversification through homomultimer and heteromultimer formation. IUBMB Life 2012; 64:64-71. 2. Thom CS, Traxler EA, Khandros E, et al. Trim58 degrades dynein and regulates terminal erythropoiesis. Dev. Cell 2014; 30:688-700.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Predicted: 53 kDa
Observed: 56 kDa
Observed: 56 kDa
NCBI Official Full Name
E3 ubiquitin-protein ligase TRIM58
NCBI Official Synonym Full Names
tripartite motif containing 58
NCBI Official Symbol
TRIM58
NCBI Official Synonym Symbols
BIA2
NCBI Protein Information
E3 ubiquitin-protein ligase TRIM58
UniProt Protein Name
E3 ubiquitin-protein ligase TRIM58
Protein Family
UniProt Gene Name
TRIM58
Uniprot Description
TRIM58: Belongs to the TRIM/RBCC family.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 1q44
Similar Products
Product Notes
The TRIM58 trim58 (Catalog #AAA154453) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TRIM58 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TRIM58 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Western blot at 1 - 2 mug/mL. Researchers should empirically determine the suitability of the TRIM58 trim58 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRIM58, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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