Testing Data
(Anti-SOCS7 at 1/1000 dilution)
Rabbit SOCS7 Polyclonal Antibody | anti-SOCS7 antibody
SOCS7 Polyclonal Antibody
Gene Names
SOCS7; NAP4; NCKAP4
Reactivity
Human, Mouse, Rat, Rabbit
Applications
Western Blot
Purity
affinity purified by Protein A
Synonyms
SOCS7; Polyclonal Antibody; SOCS7 Polyclonal Antibody; NAP 4; NAP 4 Fragment; NAP4; Nck Ash and phospholipase C binding protein; Nck Ash and phospholipase C gamma binding protein; Nck associated protein 4; NCKAP4; SH2 domain containing SOCS box protein; SOCS 7; SOCS4; SOCS6; Suppressor of cytokine signaling 7;SOCS7_HUMAN.; anti-SOCS7 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat, Rabbit
Clonality
Polyclonal
Specificity
SOCS7 Polyclonal Antibody detects endogenous levels of SOCS7 protein.
Purity/Purification
affinity purified by Protein A
Form/Format
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 107% Glycerol.
Applicable Applications for anti-SOCS7 antibody
Western Blot (WB)
Application Notes
WB: 1:500-2000
Immunogen
KLH conjugated synthetic peptide derived from human SOCS7:171-270/581
Preparation and Storage
Store at 4 degree C short term. Aliquot and store at -26 degree C long term. Avoid freeze-thaw cycles.
Testing Data
(Anti-SOCS7 at 1/1000 dilution)
Testing Data
(Anti-SOCS7 at 1/1000 dilution)
Related Product Information for anti-SOCS7 antibody
The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS1 and SOCS6 interact with the insulin receptor (IR) when expressed in human hepatoma cells (HepG2) or in rat hepatoma cells overexpressing human IR. SOCS1 and SOCS6 inhibit insulin-dependent activation of ERK1/2 and protein kinase B in vivo and IR- directed phosphorylation of IRS1 in vitro. These results suggest that SOCS proteins may be inhibitors of IR signalling and could mediate cytokine-induced insulin resistance and contribute to the pathogenesis of type II diabetes. SOCS6 and SOCS7 are expressed ubiquitously in murine tissues and SOCS6 knockout mice are growth retarded.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
37,461 Da
NCBI Official Full Name
suppressor of cytokine signaling 7
NCBI Official Synonym Full Names
suppressor of cytokine signaling 7
NCBI Official Symbol
SOCS7
NCBI Official Synonym Symbols
NAP4; NCKAP4
NCBI Protein Information
suppressor of cytokine signaling 7
UniProt Protein Name
Suppressor of cytokine signaling 7
Protein Family
UniProt Gene Name
SOCS7
UniProt Synonym Gene Names
NAP4; SOCS6
UniProt Entry Name
SOCS7_HUMAN
Research Articles on SOCS7
1. This study showed that increased protein levels of SOCS-4 and SOCS-7 in Alzheimer's disease brains.
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Product Notes
The SOCS7 socs7 (Catalog #AAA3015388) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SOCS7 Polyclonal Antibody reacts with Human, Mouse, Rat, Rabbit and may cross-react with other species as described in the data sheet. AAA Biotech's SOCS7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-2000. Researchers should empirically determine the suitability of the SOCS7 socs7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SOCS7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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