Rabbit anti-Human SOCS4 Polyclonal Antibody | anti-SOCS4 antibody

SOCS4 antibody

Cat. Num. AAA9403646

• Gene Names: SOCS4; SOCS7
• Reactivity: Human
• Applications: Western Blot, Immunofluorescence
• Purity: Purified by antigen-affinity chromatography.
• Synonyms: SOCS4; Polyclonal Antibody; SOCS4 antibody; anti-SOCS4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Purified by antigen-affinity chromatography.
• Form/Format: Supplied in 1XPBS, 40% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
• Sequence Length: 440

• Applicable Applications for anti-SOCS4 antibody: Western Blot (WB), Immunofluorescence (IF)
• Application Notes: Western blotting: 1:100-1:1000; Immunofluorescence: 1:100-1:200
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide contain a sequence corresponding to a region within amino acids 376 and 439 of SOCS4
• Target Name: SOCS4
• Preparation and Storage: Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.

Testing Data

(Sample(30 ug of whole cell lysate)A: HeLa S312% SDS PAGEPrimary antibody diluted at 1: 200)

Immunofluorescence (IF)

(Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using SOCS4 antibody at 1: 200 dilution.)

Related Product Information for anti-SOCS4 antibody

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]

Product Categories/Family for anti-SOCS4 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 18254466
• NCBI GeneID: 122809
• NCBI Accession #: NP_543143
• NCBI GenBank Nucleotide #: NM_080867.2
• Molecular Weight: 50,623 Da
• NCBI Official Full Name: suppressor of cytokine signaling 4
• NCBI Official Synonym Full Names: suppressor of cytokine signaling 4
• NCBI Official Symbol: SOCS4
• NCBI Official Synonym Symbols: SOCS7
• NCBI Protein Information: suppressor of cytokine signaling 4
• UniProt Protein Name: Suppressor of cytokine signaling 4
• Protein Family: Suppressor of cytokine signaling
• UniProt Gene Name: SOCS4
• UniProt Synonym Gene Names: SOCS7; SOCS-4; SOCS-7
• UniProt Entry Name: SOCS4_HUMAN

NCBI Description

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

SOCS4: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 14q22.1

Cellular Component: cytoplasm

Molecular Function: protein kinase inhibitor activity

Biological Process: negative regulation of epidermal growth factor receptor activity; cytokine and chemokine mediated signaling pathway; regulation of growth; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; negative regulation of JAK-STAT cascade