Rabbit anti-Human, Mouse SOCS4 Polyclonal Antibody | anti-SOCS4 antibody

SOCS4 Antibody

Cat. Num. AAA7046340

• Gene Names: SOCS4; SOCS7
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: SOCS4; Polyclonal Antibody; SOCS4 Antibody; Suppressor of cytokine signaling 4; SOCS-4; Suppressor of cytokine signaling 7; SOCS-7; SOCS7; anti-SOCS4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 440

• Applicable Applications for anti-SOCS4 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Species: Human
• Immunogen: Recombinant human Suppressor of cytokine signaling 4 protein (N-270AA)
• Conjugate: Non-conjugated
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-68827 / sc-68828 / sc-68825
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western blotAll lanes: SOCS4 antibody at 4.39 ug/mlLane 1: Mouse kidney tissueLane 2: Jurkat whole cell lysateLane 3: A549 whole cell lysateLane 4: 293T whole cell lysateSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 60 kDaObserved band size: 60 kDa)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human colon cancer using MBS7046340 at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human gastric cancer using MBS7046340 at dilution 1:100)

Related Product Information for anti-SOCS4 antibody

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.

NCBI and Uniprot Product Information

• NCBI GI #: 18254466
• NCBI GeneID: 122809
• NCBI Accession #: NP_543143.1
• NCBI GenBank Nucleotide #: NM_080867.2
• UniProt Accession #: Q8WXH5
• Molecular Weight: 50,623 Da
• NCBI Official Full Name: suppressor of cytokine signaling 4
• NCBI Official Synonym Full Names: suppressor of cytokine signaling 4
• NCBI Official Symbol: SOCS4
• NCBI Official Synonym Symbols: SOCS7
• NCBI Protein Information: suppressor of cytokine signaling 4
• UniProt Protein Name: Suppressor of cytokine signaling 4
• Protein Family: Suppressor of cytokine signaling
• UniProt Gene Name: SOCS4
• UniProt Synonym Gene Names: SOCS7; SOCS-4; SOCS-7
• UniProt Entry Name: SOCS4_HUMAN

NCBI Description

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

SOCS4: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 14q22.1

Cellular Component: cytoplasm

Molecular Function: protein binding; protein kinase inhibitor activity

Biological Process: cytokine and chemokine mediated signaling pathway; negative regulation of epidermal growth factor receptor activity; negative regulation of JAK-STAT cascade