Rabbit anti-Rat, Human Socs3 Polyclonal Antibody | anti-Socs3 antibody

Socs3 Antibody

Cat. Num. AAA968981

• Gene Names: Socs3; Cish3; Ssi-3; Socs-3
• Reactivity: Rat, Human
• Applications: ELISA, Western Blot
• Purity: >95%, Protein G Purified
• Synonyms: Socs3; Polyclonal Antibody; Socs3 Antibody; Suppressor of cytokine signaling 3; SOCS-3; Cish3; Cytokine-inducible SH2 protein 3; anti-Socs3 antibody

• Host: Rabbit
• Reactivity: Rat, Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G Purified
• Sequence Length: 225

• Applicable Applications for anti-Socs3 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: Recommended dilution: WB:1:500-2000
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: Non-conjugated
• Immunogen: Recombinant rat Suppressor of cytokine signaling 3 protein
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western blotAll lanes: Socs3 antibody at 12ug/mlLane 1: K562 whole cell lysateLane 2: A375 whole cell lysateLane 3: Hela whole cell lysateLane 4: HepG-2 whole cell lysateSecondaryGoat polyclonal to Rabbit IgG at 1/10000 dilutionPredicted band size: 25 kDaObserved band size: 25 kDa)

Related Product Information for anti-Socs3 antibody

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 16758336
• NCBI GeneID: 89829
• NCBI Accession #: NP_446017.1
• NCBI GenBank Nucleotide #: NM_053565.1
• UniProt Accession #: O88583; Q9QYV5
• Molecular Weight: 24,808 Da
• NCBI Official Full Name: suppressor of cytokine signaling 3
• NCBI Official Synonym Full Names: suppressor of cytokine signaling 3
• NCBI Official Symbol: Socs3
• NCBI Official Synonym Symbols: Cish3; Ssi-3; Socs-3
• NCBI Protein Information: suppressor of cytokine signaling 3
• UniProt Protein Name: Suppressor of cytokine signaling 3
• Protein Family: Suppressor of cytokine signaling
• UniProt Gene Name: Socs3
• UniProt Synonym Gene Names: Cish3; SOCS-3
• UniProt Entry Name: SOCS3_RAT

NCBI Description

regulates cytokine levels to modulate inflammation [RGD, Feb 2006]

Uniprot Description

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST ().