Rabbit anti-Human SNX6 Polyclonal Antibody | anti-SNX6 antibody

SNX6, NT (TRAF4-associated Factor 2, Sorting Nexin-6)

Cat. Num. AAA624347

• Gene Names: SNX6; TFAF2; MGC3157; MSTP010
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: SNX6; Polyclonal Antibody; NT (TRAF4-associated Factor 2; Sorting Nexin-6); Anti -SNX6; anti-SNX6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SNX6.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide.

• Applicable Applications for anti-SNX6 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:1,000; Western Blot: 1:50-1:100
• Immunogen: Synthetic peptide selected from the N-terminal region of human SNX6 (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of SNX6 Antibody (N-term) in HepG2 cell line lysates (35ug/lane). SNX6 (arrow) was detected using the purified Pab.)

Related Product Information for anti-SNX6 antibody

SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal. Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII. Of the type I receptors, SNX6 was found to interact only with inactivated TbetaRI. SNXs 1-4 also interacted with the transforming growth factor-beta receptor family, showing different receptor preferences. Conversely, SNX6 behaved similarly to the other SNX proteins in its interactions with receptor tyrosine kinases. Strong heteromeric interactions were also seen among SNX1, -2, -4, and -6, suggesting the formation in vivo of oligomeric complexes. These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases.

Product Categories/Family for anti-SNX6 antibody

Antibodies; Abs to SNX (Sorting Nexin) Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 88703041
• NCBI GeneID: 58533
• NCBI Accession #: NP_689419.2
• NCBI GenBank Nucleotide #: NM_152233.2
• UniProt Accession #: Q5QTQ6; Q9UNH7
• Molecular Weight: 24,652 Da
• NCBI Official Full Name: sorting nexin-6 isoform b
• NCBI Official Synonym Full Names: sorting nexin 6
• NCBI Official Symbol: SNX6
• NCBI Official Synonym Symbols: TFAF2; MGC3157; MSTP010
• NCBI Protein Information: sorting nexin-6; OTTHUMP00000178808; OTTHUMP00000178809; TRAF4-associated factor 2; tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2
• UniProt Protein Name: MSTP010
• Protein Family: Sorting nexin
• UniProt Entry Name: Q5QTQ6_HUMAN

NCBI Description

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms. [provided by RefSeq]

Uniprot Description

SNX6: May be involved in several stages of intracellular trafficking. Promotes lysosomal degradation of CDKN1B. Plays a role in retrograde protein transport from endosomes to the trans-Golgi network. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. May contribute to transcription regulation. Belongs to the sorting nexin family.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 14q13.1

Cellular Component: extrinsic to membrane; retromer complex; early endosome membrane; cytoplasm; cytoplasmic membrane-bound vesicle; intracellular; nucleus

Molecular Function: protein binding; protein homodimerization activity; phosphoinositide binding

Biological Process: negative regulation of epidermal growth factor receptor activity; intracellular protein transport; vesicle organization and biogenesis; endocytosis; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; retrograde transport, endosome to Golgi