Goat SNX4 Polyclonal Antibody | anti-SNX4 antibody

Goat Polyclonal to Human SNX4

Cat. Num. AAA247366

• Gene Names: SNX4; ATG24B
• Reactivity: Bat, Gibbon, Bovine, Dog, Gorilla, Horse, Human, Monkey, Mouse, Orangutan, Rabbit, Rat; Predicted Reactivity: Chicken, Zebrafish (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: SNX4; Polyclonal Antibody; Goat Polyclonal to Human SNX4; Anti-SNX4 Antibody (aa438-450) IHC-plus; Sorting nexin 4; Sorting nexin-4; ATG24B; Human SNX4; anti-SNX4 antibody

• Host: Goat
• Reactivity: Bat, Gibbon, Bovine, Dog, Gorilla, Horse, Human, Monkey, Mouse, Orangutan, Rabbit, Rat; Predicted Reactivity: Chicken, Zebrafish (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human SNX4. A phox (PX) domain protein. In mouse, there is also a hypothetical protein called similar to SNX4 (XP_123014.1), which is virtually identical to SNX4.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 450

• Applicable Applications for anti-SNX4 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (3.75 - 7.5 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic peptide QVWTNAKECFSKM from the C-terminus of human SNX4 (NP_003785.1). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Elephant, Dog, Bat, Bovine, Horse, Rabbit, Opossum, Turkey (100%).
• Immunogen Type: Synthetic peptide
• Immunogen: SNX4 antibody was raised against synthetic peptide QVWTNAKECFSKM from the C-terminus of human SNX4 (NP_003785.1). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Elephant, Dog, Bat, Bovine, Horse, Rabbit, Opossum, Turkey (100%); Chicken, Zebrafish (92%); Stickleback (85%).
• Antigen Modification: aa438-450
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-SNX4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Immunohistochemistry (IHC)

(Anti-SNX4 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 4507145
• NCBI GeneID: 8723
• NCBI Accession #: NP_003785.1
• NCBI GenBank Nucleotide #: NM_003794.3
• UniProt Accession #: O95219; B3KMH0; B4DQV4; D3DNA3
• Molecular Weight: 35,611 Da
• NCBI Official Full Name: sorting nexin-4
• NCBI Official Synonym Full Names: sorting nexin 4
• NCBI Official Symbol: SNX4
• NCBI Official Synonym Symbols: ATG24B
• NCBI Protein Information: sorting nexin-4
• UniProt Protein Name: Sorting nexin-4
• Protein Family: Sorting nexin
• UniProt Gene Name: SNX4
• UniProt Entry Name: SNX4_HUMAN

NCBI Description

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2012]

Uniprot Description

SNX4: May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. Belongs to the sorting nexin family.

Chromosomal Location of Human Ortholog: 3q21.2

Cellular Component: SNARE complex; protein complex; extrinsic to membrane; cytoplasmic dynein complex; membrane; early endosome membrane; cytoplasm; plasma membrane

Molecular Function: protein binding; phosphoinositide binding; insulin receptor binding; epidermal growth factor receptor binding

Biological Process: protein transport; vesicle organization and biogenesis; endocytic recycling