Western Blot (WB)
(Staining (0.5ug/ml) of 293 lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.)
Goat SNX15 Polyclonal Antibody | anti-SNX15 antibody
Goat anti-SNX15 Antibody
Western Blot: Approx 48kDa band seen in Human Kidney lysates and in lysates of cell line HEK293 (calculated MW 38.2kDa according to NP_037438.2). Recommended for use at 0.2-1ug/ml. Note: A single approx 30-35kDa band (probably representing the shorter isoform) was observed in Human Heart.
Western Blot (WB)
(Staining (0.5ug/ml) of 293 lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.)
Western Blot (WB)
(Staining (0.5ug/ml) of 293 lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010]
Uniprot Description
SNX15: May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. Belongs to the sorting nexin family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 11q12
Cellular Component: cytoplasm; cytoplasmic vesicle membrane; cytosol; intracellular membrane-bound organelle; membrane; nucleolus
Molecular Function: phosphoinositide binding; protein binding; protein serine/threonine kinase activity
Biological Process: intracellular protein transport; protein amino acid phosphorylation; signal transduction
Research Articles on SNX15
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Product Notes
The SNX15 snx15 (Catalog #AAA421490) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-SNX15 Antibody reacts with Tested: Human; Expected from sequence similarity: Human and may cross-react with other species as described in the data sheet. AAA Biotech's SNX15 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB). Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Approx 48kDa band seen in Human Kidney lysates and in lysates of cell line HEK293 (calculated MW 38.2kDa according to NP_037438.2). Recommended for use at 0.2-1ug/ml. Note: A single approx 30-35kDa band (probably representing the shorter isoform) was observed in Human Heart. Researchers should empirically determine the suitability of the SNX15 snx15 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: EEILRLHLSQ LPP. It is sometimes possible for the material contained within the vial of "SNX15, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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