Western Blot (WB)
(SNTB2 Antibody (Center) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the SNTB2 antibody detected the SNTB2 protein (arrow).)
Rabbit anti-Human SNTB2 Polyclonal Antibody | anti-SNTB2 antibody
SNTB2 Antibody (Center)
Western Blot (WB)
(SNTB2 Antibody (Center) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the SNTB2 antibody detected the SNTB2 protein (arrow).)
Western Blot (WB)
(SNTB2 Antibody (Center) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the SNTB2 antibody detected the SNTB2 protein (arrow).)
at the inner surface of muscle fibers. Dystrophin is missing in
Duchenne Muscular Dystrophy patients and is present in reduced
amounts in Becker Muscular Dystrophy patients. The protein encoded
by this gene is a peripheral membrane protein found associated with
dystrophin and dystrophin-related proteins. This gene is a member
of the syntrophin gene family, which contains at least two other
structurally-related genes.
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
NCBI and Uniprot Product Information
NCBI Description
Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes. [provided by RefSeq, Jul 2008]
Uniprot Description
SNTB2: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN. Monomer and homodimer (Probable). Interacts with the other members of the syntrophin family: SNTA1 and SNTB1; and with the sodium channel proteins SCN4A and SCN5A. Interacts with SAST, MAST205, microtubules and microtubule-associated proteins. Interacts with the dystrophin protein DMD and related proteins DTNA and UTRN, and with the neuroregulin receptor ERBB4. Interacts with PTPRN when phosphorylated, protecting PTPRN from protein cleavage by CAPN1. Dephosphorylation upon insulin stimulation disrupts the interaction with PTPRN and results in the cleavage of PTPRN. Ubiquitous. Isoform 1 is the predominant isoform. Weak level of isoform 2 is present in all tested tissues, except in liver and heart where it is highly expressed. Belongs to the syntrophin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Extracellular matrix; Dystrophin complex; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: dystrophin-associated glycoprotein complex; microtubule; focal adhesion; protein complex; membrane; cytoplasm; synapse
Molecular Function: calmodulin binding; protein binding; actin binding
Research Articles on SNTB2
Similar Products
Product Notes
The SNTB2 sntb2 (Catalog #AAA9207958) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 217-245. The SNTB2 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SNTB2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the SNTB2 sntb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SNTB2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
