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Immunofluorescence (IF) (Immunofluorescence analysis of methanol-fixed HeLa, using SNTB2 antibody at 1:200 dilution.)

Rabbit SNTB2 Polyclonal Antibody | anti-SNTB2 antibody

SNTB2 antibody

Gene Names
Sntb2; Snt2
Applications
Immunofluorescence, Immunocytochemistry, Immunohistochemistry, Western Blot
Purity
SNTB2 antibody was purified by antigen-affinity chromatography
Synonyms
SNTB2; Polyclonal Antibody; SNTB2 antibody; Polyclonal SNTB2; Anti-SNTB2; SNT2B2; 59 kDa dystrophin-associated protein A1 basic component 2; SNTB-2; SNTB 2; syntrophin-3; SNT3; SNTL; beta-2-syntrophin; D16S2531E; EST25263; dystrophin-associated protein A1 59kD basic component 2; anti-SNTB2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
SNTB2 antibody was purified by antigen-affinity chromatography
Form/Format
Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative.
Concentration
0.84 mg/ml (varies by lot)
Sequence Length
531
Applicable Applications for anti-SNTB2 antibody
Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes
IF:1:100-1:500
ICC:1:100-1:500
IHC-P: 1:100-1:500
WB: 1:500-1:3000
Biological Significance
Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes.
Cross-Reactivity
Human
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Immunofluorescence (IF)

(Immunofluorescence analysis of methanol-fixed HeLa, using SNTB2 antibody at 1:200 dilution.)

Immunofluorescence (IF) (Immunofluorescence analysis of methanol-fixed HeLa, using SNTB2 antibody at 1:200 dilution.)

Western Blot (WB)

(Western blot analysis of 30 ug of whole cell lysate (A: Hep G2) using a 7.5 % SDS PAGE gel and SNTB2 antibody at a dilution of 1:3000)

Western Blot (WB) (Western blot analysis of 30 ug of whole cell lysate (A: Hep G2) using a 7.5 % SDS PAGE gel and SNTB2 antibody at a dilution of 1:3000)

Immunohistochemistry (IHC)

(Immunohistochemical staining of paraffin-embedded OVCAR3 xenograft using SNTB2 antibody at a dilution of 1:500)

Immunohistochemistry (IHC) (Immunohistochemical staining of paraffin-embedded OVCAR3 xenograft using SNTB2 antibody at a dilution of 1:500)
Related Product Information for anti-SNTB2 antibody
Affinity purified Rabbit polyclonal SNTB2 antibody
Product Categories/Family for anti-SNTB2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
58 kDa
NCBI Official Full Name
Sntb2 protein
NCBI Official Synonym Full Names
syntrophin, basic 2
NCBI Official Symbol
Sntb2
NCBI Official Synonym Symbols
Snt2
NCBI Protein Information
beta-2-syntrophin
UniProt Protein Name
Beta-2-syntrophin
Protein Family
UniProt Gene Name
Sntb2
UniProt Synonym Gene Names
Snt2b2; SNT3; SNTL
UniProt Entry Name
SNTB2_MOUSE

Uniprot Description

SNTB2: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN. Monomer and homodimer (Probable). Interacts with the other members of the syntrophin family: SNTA1 and SNTB1; and with the sodium channel proteins SCN4A and SCN5A. Interacts with SAST, MAST205, microtubules and microtubule-associated proteins. Interacts with the dystrophin protein DMD and related proteins DTNA and UTRN, and with the neuroregulin receptor ERBB4. Interacts with PTPRN when phosphorylated, protecting PTPRN from protein cleavage by CAPN1. Dephosphorylation upon insulin stimulation disrupts the interaction with PTPRN and results in the cleavage of PTPRN. Ubiquitous. Isoform 1 is the predominant isoform. Weak level of isoform 2 is present in all tested tissues, except in liver and heart where it is highly expressed. Belongs to the syntrophin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Extracellular matrix; Adaptor/scaffold; Dystrophin complex

Cellular Component: microtubule; focal adhesion; protein complex; cytoskeleton; membrane; cytoplasm; synapse; cytoplasmic vesicle; cell junction

Molecular Function: calmodulin binding; protein binding; actin binding

Research Articles on SNTB2

Similar Products

Product Notes

The SNTB2 sntb2 (Catalog #AAA835687) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's SNTB2 can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Paraffin, Western Blot (WB). IF:1:100-1:500 ICC:1:100-1:500 IHC-P: 1:100-1:500 WB: 1:500-1:3000. Researchers should empirically determine the suitability of the SNTB2 sntb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SNTB2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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