Rabbit anti-Human, Mouse SNTB1 Polyclonal Antibody | anti-SNTB1 antibody

SNTB1, ID (SNTB1, SNT2B1, Beta-1-syntrophin, 59kD dystrophin-associated protein A1 basic component 1, BSYN2, Syntrophin-2, Tax interaction protein 43) (Biotin)

Cat. Num. AAA6349454

• Gene Names: SNTB1; A1B; SNT2; BSYN2; 59-DAP; DAPA1B; SNT2B1; TIP-43
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SNTB1; Polyclonal Antibody; ID (SNTB1; SNT2B1; Beta-1-syntrophin; 59kD dystrophin-associated protein A1 basic component 1; BSYN2; Syntrophin-2; Tax interaction protein 43) (Biotin); Tax interaction protein 43; anti-SNTB1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-SNTB1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: SNTB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-271 amino acids from the Central region of human SNTB1.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(SNTB1 Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SNTB1 antibody detected the SNTB1 protein (arrow).)

Western Blot (WB)

(SNTB1 Antibody (Center) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the SNTB1 antibody detected the SNTB1 protein (arrow).)

Related Product Information for anti-SNTB1 antibody

Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes.

Product Categories/Family for anti-SNTB1 antibody

Antibodies; Proteins

References

Rothenberg, M.E., et al. Nat. Genet. 42(4):289-291(2010). Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007). Chen, Z., et al. J. Biol. Chem. 281(18):12414-12420(2006). Ejtehadi, H.D., et al. Ann. Rheum. Dis. 65(5):612-616(2006). Kawai-Yamada, M., et al. J. Biol. Chem. 280(47):39468-39473(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 11321640
• NCBI GeneID: 6641
• NCBI Accession #: NP_066301.1
• NCBI GenBank Nucleotide #: NM_021021.3
• UniProt Accession #: Q13884; O14912; Q4KMG8; A8K9E0
• Molecular Weight: 58,061 Da
• NCBI Official Full Name: beta-1-syntrophin
• NCBI Official Synonym Full Names: syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
• NCBI Official Symbol: SNTB1
• NCBI Official Synonym Symbols: A1B; SNT2; BSYN2; 59-DAP; DAPA1B; SNT2B1; TIP-43
• NCBI Protein Information: beta-1-syntrophin; syntrophin-2; tax interaction protein 43; 59 kDa dystrophin-associated protein A1 basic component 1; dystrophin-associated protein A1, 59kD, basic component 1
• UniProt Protein Name: Beta-1-syntrophin
• Protein Family: Beta-1-syntrophin
• UniProt Gene Name: SNTB1
• UniProt Synonym Gene Names: SNT2B1; DAPA1B; TIP-43
• UniProt Entry Name: SNTB1_HUMAN

Uniprot Description

SNTB1: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. Belongs to the syntrophin family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 8q23-q24

Cellular Component: dystrophin-associated glycoprotein complex; protein complex; focal adhesion; cytoskeleton; cytoplasm; synapse; sarcolemma

Molecular Function: calmodulin binding; protein binding; actin binding; PDZ domain binding

Biological Process: muscle contraction