Rabbit anti-Human SNTA1 Polyclonal Antibody | anti-SNTA1 antibody

SNTA1 Antibody - N-terminal region

Cat. Num. AAA3220420

• Gene Names: SNTA1; SNT1; LQT12; TACIP1; dJ1187J4.5
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity purified
• Synonyms: SNTA1; Polyclonal Antibody; SNTA1 Antibody - N-terminal region; anti-SNTA1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Affinity purified
• Form/Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Sequence: Synthetic peptide located within the following region: QRVLLSLAEDVLTVSPADGDPGPEPGAPREQEPAQLNGAAEPGAGPPQLP
• Sequence Length: 167

• Applicable Applications for anti-SNTA1 antibody: Western Blot (WB)
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SNTA1
• Preparation and Storage: For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Host: RabbitTarget Name: SNTA1Sample Tissue: Human Hela Whole CellAntibody Dilution: 1.0ug/ml)

Related Product Information for anti-SNTA1 antibody

Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue.

Product Categories/Family for anti-SNTA1 antibody

Polyclonal

NCBI and Uniprot Product Information

• NCBI GI #: 4507137
• NCBI GeneID: 6640
• NCBI Accession #: NP_003089.1
• NCBI GenBank Nucleotide #: NM_003098.2
• UniProt Accession #: Q13424
• Molecular Weight: 54 kDa
• NCBI Official Full Name: alpha-1-syntrophin
• NCBI Official Synonym Full Names: syntrophin alpha 1
• NCBI Official Symbol: SNTA1
• NCBI Official Synonym Symbols: SNT1; LQT12; TACIP1; dJ1187J4.5
• NCBI Protein Information: alpha-1-syntrophin
• UniProt Protein Name: Alpha-1-syntrophin
• Protein Family: Alpha-1-syntrophin
• UniProt Gene Name: SNTA1
• UniProt Synonym Gene Names: SNT1; TACIP1
• UniProt Entry Name: SNTA1_HUMAN

NCBI Description

Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013]

Uniprot Description

SNTA1: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5- bisphosphate. Defects in SNTA1 are the cause of long QT syndrome type 12 (LQT12). A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. Belongs to the syntrophin family.

Protein type: Adaptor/scaffold; Membrane protein, peripheral; Lipid-binding

Chromosomal Location of Human Ortholog: 20q11.2

Cellular Component: postsynaptic membrane; cytoskeleton; protein complex; cytoplasm; syntrophin complex; intracellular; cell junction; neuromuscular junction; sarcolemma; lateral plasma membrane

Molecular Function: calmodulin binding; protein binding; sodium channel regulator activity; actin binding; nitric-oxide synthase binding; ATPase binding; PDZ domain binding

Biological Process: muscle contraction; regulation of vasoconstriction by circulating norepinephrine; regulation of heart rate; neuromuscular junction development

Disease: Long Qt Syndrome 12