Western Blot (WB)
(Anti-SNRPN antibody, MBS175473, Western blottingLane 1: Rat kidney Tissue LysateLane 2: U87 Cell LysateLane 3: U87 Cell LysateLane 4: HELA Cell LysateLane 5: HMY Cell LysateLane 6: NEUR Cell Lysate )
Rabbit SNRPN Polyclonal Antibody | anti-SNRPN antibody
Anti-SNRPN antibody
Western Blot (WB)
(Anti-SNRPN antibody, MBS175473, Western blottingLane 1: Rat kidney Tissue LysateLane 2: U87 Cell LysateLane 3: U87 Cell LysateLane 4: HELA Cell LysateLane 5: HMY Cell LysateLane 6: NEUR Cell Lysate )
Western Blot (WB)
(Anti-SNRPN antibody, MBS175473, Western blottingLane 1: Rat kidney Tissue LysateLane 2: U87 Cell LysateLane 3: U87 Cell LysateLane 4: HELA Cell LysateLane 5: HMY Cell LysateLane 6: NEUR Cell Lysate )
Immunohistochemistry (IHC)
(Anti-SNRPN antibody, MBS175473, IHC(P)IHC(P): Human Intestinal Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-SNRPN antibody, MBS175473, IHC(P)IHC(P): Human Intestinal Cancer Tissue )
Immunocytochemistry (ICC)
(Anti-SNRPN antibody, MBS175473, ICCICC: HELA Cell )
Immunocytochemistry (ICC)
(Anti-SNRPN antibody, MBS175473, ICCICC: HELA Cell )
Background: SNRPN(Small Nuclear Ribonucleoprotein Polypeptide N), also called SMN, is a bicistronic imprinted gene that encodes 2 polypeptides, the SmN splicing factor, which is involved in RNA processing, and the SNRPN upstream reading frame(SNURF) polypeptide. The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. SNRPN also encodes a long alternatively spliced transcript containing several small nucleolar RNAs(snoRNAs) and extends downstream to partially overlap the UBE3A gene in the antisense orientation. PWS arises from loss of function of genes in this region expressed exclusively from the paternal chromosome, suggesting that SNRPN may play a role in its etiology. The SNRPN gene is mapped on 15q11.2. Analysis of maternal DNA and of SNRPN cDNA confirmed that the maternal allele is not expressed in fetal brain and heart. Deletions in the transcription unit of the imprinted SNRPN gene occur in patients who have PWS or Angelman syndrome because of a parental imprint switch failure in this chromosomal domain.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. [provided by RefSeq, Jul 2008]
Uniprot Description
snRNP N: May be involved in tissue-specific alternative RNA processing events. Belongs to the snRNP SmB/SmN family.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 15q11.2
Cellular Component: small nuclear ribonucleoprotein complex; spliceosome; snRNP U2; snRNP U1
Molecular Function: protein binding; RNA binding
Biological Process: RNA splicing; response to hormone stimulus
Disease: Prader-willi Syndrome; Autism
Research Articles on SNRPN
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Product Notes
The SNRPN snrpn (Catalog #AAA175473) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-SNRPN antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SNRPN can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC). Researchers should empirically determine the suitability of the SNRPN snrpn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SNRPN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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