Goat SNM1/DCLRE1A Polyclonal Antibody | anti-DCLRE1A antibody
Goat anti-SNM1/DCLRE1A (internal) Antibody
Gene Names
DCLRE1A; PSO2; SNM1; SNM1A
Reactivity
Expected from sequence similarity: Human
Applications
ELISA
Purity
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Synonyms
SNM1/DCLRE1A; Polyclonal Antibody; Goat anti-SNM1/DCLRE1A (internal) Antibody; Goat Anti-SNM1 (C Term) Antibody; DCLRE1A; DNA cross-link repair 1A (PSO2 homolog; S. cerevisiae); HGNC: 17660; KIAA0086; PSO2; SNM1; DNA-crosslink repair gene SNM1; SNM1A; DNA cross-link repair 1A; OTTHUMP00000020516; DCLRE1A antibody; S. cerevisiae) antibody; HGNC: 17660 antibody; KIAA0086 antibody; PSO2 antibody; SNM1 antibody; DNA-crosslink repair gene SNM1 antibody; SNM1A antibody; DNA cross-link repair 1A antibody; OTTHUMP00000020516 antibody; SNM1 / DCLRE1A (internal); anti-DCLRE1A antibody
Host
Goat
Reactivity
Expected from sequence similarity: Human
Clonality
Polyclonal
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (varies by lot)
Sequence
PSPNQKRSSQCKRK
Sequence Length
1040
Applicable Applications for anti-DCLRE1A antibody
Peptide ELISA (EIA)
Application Notes
Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Preliminary experiments gave an approx 26kDa band in human duodenum lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 117kDa according to NP_055696.2. The 26kDa band was successfully blocked by incubation with the immunizing peptide.
Western Blot: Preliminary experiments gave an approx 26kDa band in human duodenum lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 117kDa according to NP_055696.2. The 26kDa band was successfully blocked by incubation with the immunizing peptide.
Immunogen
Peptide with sequence PSPNQKRSSQCKRK, from the internal region of the protein sequence according to NP_055696.3.
Epitope
Internal region
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
116,400 Da
NCBI Official Full Name
DNA cross-link repair 1A protein
NCBI Official Synonym Full Names
DNA cross-link repair 1A
NCBI Official Symbol
DCLRE1A
NCBI Official Synonym Symbols
PSO2; SNM1; SNM1A
NCBI Protein Information
DNA cross-link repair 1A protein
UniProt Protein Name
DNA cross-link repair 1A protein
Protein Family
UniProt Gene Name
DCLRE1A
UniProt Synonym Gene Names
KIAA0086; SNM1; SNM1A; hSNM1; hSNM1A
UniProt Entry Name
DCR1A_HUMAN
NCBI Description
This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Uniprot Description
DCLRE1A: May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
Chromosomal Location of Human Ortholog: 10q25.1
Cellular Component: nuclear chromosome, telomeric region; nucleolus; nucleoplasm; nucleus
Molecular Function: 5'-3' exodeoxyribonuclease activity; damaged DNA binding
Biological Process: cell division; double-strand break repair via nonhomologous end joining; mitosis; protection from non-homologous end joining at telomere
Research Articles on DCLRE1A
Similar Products
Product Notes
The DCLRE1A dclre1a (Catalog #AAA420731) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-SNM1/DCLRE1A (internal) Antibody reacts with Expected from sequence similarity: Human and may cross-react with other species as described in the data sheet. AAA Biotech's SNM1/DCLRE1A can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Preliminary experiments gave an approx 26kDa band in human duodenum lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 117kDa according to NP_055696.2. The 26kDa band was successfully blocked by incubation with the immunizing peptide. Researchers should empirically determine the suitability of the DCLRE1A dclre1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: PSPNQKRSSQ CKRK. It is sometimes possible for the material contained within the vial of "SNM1/DCLRE1A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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