Rabbit anti-Human, Mouse SMG8 Polyclonal Antibody | anti-SMG8 antibody
SMG8 Antibody
Gene Names
SMG8; C17orf71
Reactivity
Human, Mouse
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
SMG8; Polyclonal Antibody; SMG8 Antibody; ABC 2; ABC2; Amplified in breast cancer gene 2 protein; Chromosome 17 open reading; chromosome 17 open reading frame 71; FLJ10587; Protein smg 8 homolog; protein SMG8; SMG8 protein; anti-SMG8 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
SMG8 Antibody detects endogenous levels of SMG8.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-SMG8 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human SMG8.
Conjugation
Unconjugated
Similarity
Belongs to the SMG8 family.
Post Translational Modifications
Phosphorylated by SMG1.
Subunit Structure
Component of the SMG1C complex composed of SMG1, SMG8 and SMG9; the recruitment of SMG8 to SMG1 N-terminus induces a large conformational change in the SMG1 C-terminal head domain containing the catalytic domain. Forms heterodimers with SMG9; this assembly form may represent a SMG1C intermediate form.
Function
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-SMG8 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
109,684 Da
NCBI Official Full Name
protein SMG8
NCBI Official Synonym Full Names
SMG8 nonsense mediated mRNA decay factor
NCBI Official Symbol
SMG8
NCBI Official Synonym Symbols
C17orf71
NCBI Protein Information
protein SMG8; protein smg-8 homolog; amplified in breast cancer gene 2 protein; smg-8 homolog, nonsense mediated mRNA decay factor
UniProt Protein Name
Protein SMG8
Protein Family
UniProt Gene Name
SMG8
UniProt Synonym Gene Names
ABC2; C17orf71
UniProt Entry Name
SMG8_HUMAN
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Product Notes
The SMG8 smg8 (Catalog #AAA9631090) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SMG8 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SMG8 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the SMG8 smg8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SMG8, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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