Rabbit smcr8b Polyclonal Antibody | anti-smcr8b antibody

Rabbit anti-Danio rerio (Zebrafish)(Brachydanio rerio) smcr8b Polyclonal Antibody

• Gene Names: smcr8b; smcr8
• Reactivity: Danio rerio (Zebrafish)(Brachydanio rerio)
• Applications: ELISA, Western Blot
• Purity: Protein A/G
• Synonyms: smcr8b; Polyclonal Antibody; Rabbit anti-Danio rerio (Zebrafish)(Brachydanio rerio) smcr8b Polyclonal Antibody; smcr8b Antibody; Guanine nucleotide exchange protein smcr8b; Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog B; smcr8b smcr8; anti-smcr8b antibody

• Host: Rabbit
• Reactivity: Danio rerio (Zebrafish)(Brachydanio rerio)
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Protein A/G
• Form/Format: Liquid; Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, pH7.4

• Applicable Applications for anti-smcr8b antibody: ELISA (EIA), WB (Western Blot) (ensure identification of antigen)
• Immunogen: Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) smcr8b protein
• Conjugation: Non-conjugate
• Modification: Unmodified
• Deliverables: 1. 200ug recombinant immunogen protein/peptide (positive control).; 2. 1mL preimmune serum (negative control); 3. 10mg rabbit polyclonal antibody purified by Protein A/G.
• Quality Guarantee: 1. Antibody purity >90% confirmed by SDS-PAGE.; 2. Antibody titer > 1: 64,000 confirmed by ELISA; 3. Western Blot positive for the immunogen protein (Not applicable for synthetic peptide).
• Complementary Antibody: Customer can choose 1 FREE antibody from the list below. Please specify the catalog # when order:; * 6*His Monoclonal Antibody #MBS1491670; * DYKDDDDK tag Monoclonal Antibody #MBS1493946; * GAPDH Monoclonal Antibody #MBS1495524; * GFP Monoclonal Antibody #MBS1496050; * Myc tag Monoclonal Antibody #MBS1497694; * GST Monoclonal Antibody #MBS1497871; * Sumo tag Monoclonal Antibody #MBS1498878; * Goat Anti-Rabbit IgG (H+L) Antibody; HRP conjugated #MBS7053510; * HA-Tag Monoclonal Antibody #MBS7135631; * E-Tag Monoclonal Antibody #MBS7135632; * TUBA1A Monoclonal Antibody #MBS7135645; * TUBB Monoclonal Antibody #MBS9018332
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

NCBI and Uniprot Product Information

• NCBI GI #: 47550897
• NCBI GeneID: 407723
• NCBI Accession #: NP_999967.1
• NCBI GenBank Nucleotide #: NM_214802.1
• UniProt Accession #: Q6PUR7
• Molecular Weight: 110,604 Da
• NCBI Official Full Name: guanine nucleotide exchange protein smcr8b
• NCBI Official Synonym Full Names: Smith-Magenis syndrome chromosome region, candidate 8b
• NCBI Official Symbol: smcr8b
• NCBI Official Synonym Symbols: smcr8
• NCBI Protein Information: guanine nucleotide exchange protein smcr8b
• UniProt Protein Name: Guanine nucleotide exchange protein smcr8b
• Protein Family: Smith-Magenis syndrome chromosomal region candidate gene 8-B protein
• UniProt Gene Name: smcr8b
• UniProt Synonym Gene Names: smcr8

Uniprot Description

Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity.