Rabbit SMAD3 Polyclonal Antibody | anti-SMAD3 antibody

Rabbit anti-Mus musculus (Mouse) SMAD3 Polyclonal Antibody

• Gene Names: Smad3; Madh3; AU022421
• Reactivity: Mus musculus (Mouse)
• Applications: ELISA, Western Blot
• Purity: Protein A/G
• Synonyms: SMAD3; Polyclonal Antibody; Rabbit anti-Mus musculus (Mouse) SMAD3 Polyclonal Antibody; SMAD3 Antibody; Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; mMad3; SMAD family member 3; SMAD 3; Smad3; Smad3 Madh3; anti-SMAD3 antibody

• Host: Rabbit
• Reactivity: Mus musculus (Mouse)
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Protein A/G
• Form/Format: Liquid; Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, pH7.4

• Applicable Applications for anti-SMAD3 antibody: ELISA (EIA), WB (Western Blot) (ensure identification of antigen)
• Immunogen: Recombinant Mus musculus (Mouse) Smad3 protein
• Conjugation: Non-conjugate
• Modification: Unmodified
• Deliverables: 1. 200ug recombinant immunogen protein/peptide (positive control).; 2. 1mL preimmune serum (negative control); 3. 10mg rabbit polyclonal antibody purified by Protein A/G.
• Quality Guarantee: 1. Antibody purity >90% confirmed by SDS-PAGE.; 2. Antibody titer > 1: 64,000 confirmed by ELISA; 3. Western Blot positive for the immunogen protein (Not applicable for synthetic peptide).
• Complementary Antibody: Customer can choose 1 FREE antibody from the list below. Please specify the catalog # when order:; * 6*His Monoclonal Antibody #MBS1491670; * DYKDDDDK tag Monoclonal Antibody #MBS1493946; * GAPDH Monoclonal Antibody #MBS1495524; * GFP Monoclonal Antibody #MBS1496050; * Myc tag Monoclonal Antibody #MBS1497694; * GST Monoclonal Antibody #MBS1497871; * Sumo tag Monoclonal Antibody #MBS1498878; * Goat Anti-Rabbit IgG (H+L) Antibody; HRP conjugated #MBS7053510; * HA-Tag Monoclonal Antibody #MBS7135631; * E-Tag Monoclonal Antibody #MBS7135632; * TUBA1A Monoclonal Antibody #MBS7135645; * TUBB Monoclonal Antibody #MBS9018332
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

NCBI and Uniprot Product Information

• NCBI GI #: 254675249
• NCBI GeneID: 17127
• NCBI Accession #: NP_058049.3
• NCBI GenBank Nucleotide #: NM_016769.4
• UniProt Accession #: Q8BUN5; O09064; O09144; O14510; O35273; Q8BX84; Q92940; Q93002; Q9GKR4
• Molecular Weight: 48,081 Da
• NCBI Official Full Name: mothers against decapentaplegic homolog 3
• NCBI Official Synonym Full Names: SMAD family member 3
• NCBI Official Symbol: Smad3
• NCBI Official Synonym Symbols: Madh3; AU022421
• NCBI Protein Information: mothers against decapentaplegic homolog 3
• UniProt Protein Name: Mothers against decapentaplegic homolog 3
• Protein Family: Mothers against decapentaplegic
• UniProt Gene Name: Smad3
• UniProt Synonym Gene Names: Madh3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; mMad3; SMAD 3; Smad3

Uniprot Description

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator ().