Rabbit SLM2 Polyclonal Antibody | anti-SLM2 antibody

Anti-SLM2 Antibody

Cat. Num. AAA8292321

• Gene Names: KHDRBS3; Etle; SALP; SLM2; SLM-2; TSTAR; T-STAR; etoile
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Purified by immunogen affinity chromatography
• Synonyms: SLM2; Polyclonal Antibody; Anti-SLM2 Antibody; SALP; KH domain-containing; RNA-binding; signal transduction-associated protein 3; RNA-binding protein T-Star; Sam68-like mammalian protein 2; SLM-2; Sam68-like phosphotyrosine protein; anti-SLM2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of SLM2 protein.
• Purity/Purification: Purified by immunogen affinity chromatography
• Form/Format: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
• Sequence Length: 271

• Applicable Applications for anti-SLM2 antibody: Western Blot (WB)
• Application Notes: WB: 1/500 - 1/2000
• Immunogen: Recombinant full length protein of human SLM2
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of SLM2 expression in HepG2 (A), Jurkat (B) whole cell lysates.)

Related Product Information for anti-SLM2 antibody

Rabbit polyclonal antibody to SLM2

NCBI and Uniprot Product Information

• NCBI GI #: 5730073
• NCBI GeneID: 10656
• NCBI Accession #: NP_006549.1
• NCBI GenBank Nucleotide #: NM_006558.2
• UniProt Accession #: O75525; Q6NUL8; Q9UPA8
• Molecular Weight: 30,250 Da
• NCBI Official Full Name: KH domain-containing, RNA-binding, signal transduction-associated protein 3
• NCBI Official Synonym Full Names: KH RNA binding domain containing, signal transduction associated 3
• NCBI Official Symbol: KHDRBS3
• NCBI Official Synonym Symbols: Etle; SALP; SLM2; SLM-2; TSTAR; T-STAR; etoile
• NCBI Protein Information: KH domain-containing, RNA-binding, signal transduction-associated protein 3
• UniProt Protein Name: KH domain-containing, RNA-binding, signal transduction-associated protein 3
• Protein Family: Phosphatidylinositol 4,5-bisphosphate-binding protein
• UniProt Gene Name: KHDRBS3
• UniProt Synonym Gene Names: SALP; SLM2; SLM-2

Uniprot Description

RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:10564820, PubMed:19561594, PubMed:26758068). Involved in splice site selection of vascular endothelial growth factor (PubMed:15901763). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PubMed:26758068). Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity (). May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing (). Can bind FABP9 mRNA (). May play a role as a negative regulator of cell growth. Inhibits cell proliferation.