Rabbit SLITRK6 Polyclonal Antibody | anti-SLITRK6 antibody

Rabbit Polyclonal to Human SLITRK6

Cat. Num. AAA242572

• Gene Names: SLITRK6; DFNMYP
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: SLITRK6; Polyclonal Antibody; Rabbit Polyclonal to Human SLITRK6; Anti-SLITRK6 Antibody (Internal) IHC-plus; Slit and trk like gene 6; SLIT and NTRK-like protein 6; Human SLITRK6; anti-SLITRK6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 841

• Applicable Applications for anti-SLITRK6 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA, IHC-P (10 ug/ml), WB (0.5 - 1 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: 13amino acid peptide from near the center of human Slitrk6.
• Immunogen: SLITRK6 antibody was raised against 13amino acid peptide from near the center of human Slitrk6.
• Antigen Modification: Internal
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-SLITRK6 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Immunohistochemistry (IHC)

(Anti-SLITRK6 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Immunofluorescence (IF)

(Immunofluorescence of Slitrk6 in Human Brain cells with Slitrk6 antibody at 20 ug/ml.)

Western Blot (WB)

(Western blot of Slitrk6 in mouse lung tissue lysate with Slitrk6 antibody at (A) 0.5 and (B) 1 ug/ml.)

Related Product Information for anti-SLITRK6 antibody

SLITEK6 is a member of the SLITRK (SLIT-and NTRK-like Famliy) family of proteins. These proteins are primarily expressed in brain and control neurite outgrowth. SLITEK6 is an integral membrane protein with 2 N-terminal leucine-rich repeats (LRR) domains and a C-terminal domain that shares homology with neurotrophin receptors. SLITRK6 is highly expressed in thalamus and putamen and unlike other family members also in lung and medulloblastomas.

NCBI and Uniprot Product Information

• NCBI GI #: 40217825
• NCBI GeneID: 84189
• NCBI Accession #: NP_115605.2
• NCBI GenBank Nucleotide #: NM_032229.2
• UniProt Accession #: Q9H5Y7; Q495Q0; Q6AW93; Q9HAA8; Q9NT60; A8K9S8
• Molecular Weight: 95,110 Da
• NCBI Official Full Name: SLIT and NTRK-like protein 6
• NCBI Official Synonym Full Names: SLIT and NTRK-like family, member 6
• NCBI Official Symbol: SLITRK6
• NCBI Official Synonym Symbols: DFNMYP
• NCBI Protein Information: SLIT and NTRK-like protein 6; 4832410J21Rik; slit and trk like gene 6
• UniProt Protein Name: SLIT and NTRK-like protein 6
• Protein Family: SLIT and NTRK-like protein
• UniProt Gene Name: SLITRK6
• UniProt Entry Name: SLIK6_HUMAN

NCBI Description

This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. This protein functions as a regulator of neurite outgrowth required for normal hearing and vision. Mutations in this gene are a cause of myopia and deafness. [provided by RefSeq, Dec 2014]

Uniprot Description

SLITRK6: Suppresses neurite outgrowth. Belongs to the SLITRK family.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q31.1

Cellular Component: cell surface; integral to plasma membrane

Biological Process: lens development in camera-type eye; vestibulocochlear nerve development; startle response; sensory perception of sound; synaptogenesis; visual perception; axonogenesis; adult locomotory behavior; multicellular organism growth; auditory receptor cell morphogenesis; auditory behavior; linear vestibuloocular reflex

Disease: Deafness And Myopia