Rabbit anti-Human, Mouse SLITRK1 Polyclonal Antibody | anti-SLITRK1 antibody

SLITRK1 Antibody

Cat. Num. AAA9630983

• Gene Names: SLITRK1; TTM; LRRC12
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: SLITRK1; Polyclonal Antibody; SLITRK1 Antibody; FLJ54428; KIAA0918; KIAA1910; Leucine rich repeat containing protein 12; LRRC1; LRRC12; RP11-395N17.1; SLIT and NTRK like family; member 1; SLIT and NTRK-like protein 1; slit and trk like gene 1; SLITRK 1; TTM; UNQ233/PRO266; anti-SLITRK1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: SLITRK1 Antibody detects endogenous levels of SLITRK1.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-SLITRK1 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human SLITRK1.
• Conjugation: Unconjugated
• Similarity: Belongs to the SLITRK family.
• Post Translational Modifications: Undergoes proteolytic cleavage that results in shedding of the ectodomain and cleavage of the C-terminal cytoplasmic tail. Glycosylated. Phosphorylation at Ser-695 is necessary for proper function in promoting neurite outgrowth.
• Subunit Structure: Can form homodimers; homodimerization requires repeat LRR 2. Interacts with YWHAB, YWHAE, YWHAG, YWHAH, SFN, YWHAQ and YWHAZ.
• Tissue Specificity: Expressed predominantly in the frontal lobe of the cerebral cortex of the brain. Also expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors.
• Function: It is involved in synaptogenesis and promotes excitatory synapse differentiation. Enhances neuronal dendrite outgrowth.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-SLITRK1 antibody

Membrane; Single-pass type I membrane protein; Secreted; Cell junction; Synapse; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 40217817
• NCBI GeneID: 114798
• NCBI Accession #: NP_443142
• NCBI GenBank Nucleotide #: NM_052910.2
• UniProt Accession #: Q96PX8; Q5U5I6; Q96SF9
• Molecular Weight: 77,735 Da
• NCBI Official Full Name: SLIT and NTRK-like protein 1
• NCBI Official Synonym Full Names: SLIT and NTRK-like family, member 1
• NCBI Official Symbol: SLITRK1
• NCBI Official Synonym Symbols: TTM; LRRC12
• NCBI Protein Information: SLIT and NTRK-like protein 1; slit and trk like gene 1; leucine-rich repeat-containing protein 12
• UniProt Protein Name: SLIT and NTRK-like protein 1
• Protein Family: SLIT and NTRK-like protein
• UniProt Gene Name: SLITRK1
• UniProt Synonym Gene Names: KIAA1910; LRRC12
• UniProt Entry Name: SLIK1_HUMAN

NCBI Description

This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

SLITRK1: Enhances neuronal dendrite outgrowth. Defects in SLITRK1 may be a cause of Gilles de la Tourette syndrome (GTS). GTS is a neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities. Defects in SLITRK1 may be a cause of trichotillomania (TTM). It is a neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical complications and often have overlapping psychologic disorders, such as Gilles de la Tourette syndrome or obsessive-compulsive disorder. Belongs to the SLITRK family.

Protein type: Membrane protein, integral; Cell development/differentiation

Chromosomal Location of Human Ortholog: 13q31.1

Cellular Component: integral to membrane

Biological Process: axonogenesis; homeostatic process; multicellular organism growth; adult behavior

Disease: Gilles De La Tourette Syndrome; Trichotillomania