Rabbit SLC9A3 Polyclonal Antibody | anti-SLC9A3 antibody

SLC9A3 Antibody

Cat. Num. AAA9610253

• Gene Names: SLC9A3; NHE3; DIAR8; NHE-3
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Synonyms: SLC9A3; Polyclonal Antibody; SLC9A3 Antibody; MGC126718; MGC126720; Na(+)/H(+) exchanger 3; NHE 3; NHE-3; NHE3; SL9A3_HUMAN; SLC9A 3; Slc9a3; Sodium/hydrogen exchanger 3; Sodium/hydrogen exchanger; apical epithelial; Solute carrier family 9 (sodium/hydrogen exchanger); isoform 3; member 3; Solute carrier family 9 member 3; anti-SLC9A3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: SLC9A3 antibody detects endogenous levels of total SLC9A3
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 825

• Applicable Applications for anti-SLC9A3 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:1000-3000
• Immunogen: A synthesized peptide derived from human SLC9A3
• Subcellular Location: Membrane. In intestinal epithelial cells, localizes to the ileal brush border.
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot analysis SLC9A3 using COLO205 whole cell lysates)

Related Product Information for anti-SLC9A3 antibody

Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773). Plays an important role in signal transduction.
Subunit Structure: Binds SLC9A3R1 and SLC9A3R2. Interacts with CHP1, CHP2 and SHANK2. Interacts with PDZK1 (via C-terminal PDZ domain) (By similarity). Interacts with PDZD3 and interactions decrease in response to elevated calcium ion levels. Interacts with AHCYL1; the interaction is required for SLC9A3 activity (PubMed:18829453, PubMed:20584908).
Post-translational Modifications: Phosphorylated by PKA, which inhibits activity. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane.
Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

NCBI and Uniprot Product Information

• NCBI GI #: 547235625
• NCBI GeneID: 6550
• NCBI Accession #: NP_001271280.1
• NCBI GenBank Nucleotide #: NM_001284351.2
• UniProt Accession #: P48764; Q3MIW3; B7ZKR2; E9PF67
• Molecular Weight: Observed: 93 kDa; Predicted: 93 kDa
• NCBI Official Full Name: sodium/hydrogen exchanger 3 isoform 2
• NCBI Official Synonym Full Names: solute carrier family 9 member A3
• NCBI Official Symbol: SLC9A3
• NCBI Official Synonym Symbols: NHE3; DIAR8; NHE-3
• NCBI Protein Information: sodium/hydrogen exchanger 3
• UniProt Protein Name: Sodium/hydrogen exchanger 3
• Protein Family: Sodium/hydrogen exchanger
• UniProt Gene Name: SLC9A3
• UniProt Synonym Gene Names: NHE-31 PublicationManual assertion based on opinion iniRef.1

NCBI Description

The protein encoded by this gene is an epithelial brush border Na/H exchanger that uses an inward sodium ion gradient to expel acids from the cell. Defects in this gene are a cause of congenital secretory sodium diarrhea. Pseudogenes of this gene exist on chromosomes 10 and 22. [provided by RefSeq, Mar 2016]

Uniprot Description

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773). Plays an important role in signal transduction.