Rabbit SLC7A9 Polyclonal Antibody | anti-SLC7A9 antibody

SLC7A9 Polyclonal Antibody

Cat. Num. AAA2516442

• Gene Names: SLC7A9; BAT1; CSNU3
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: SLC7A9; Polyclonal Antibody; SLC7A9 Polyclonal Antibody; BAT1; CSNU3; anti-SLC7A9 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 2.4mg/mL (varies by lot)
• Sequence Length: 487

• Applicable Applications for anti-SLC7A9 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:25-1:100
• Immunogen: Synthetic peptide of human SLC7A9
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using SLC7A9 Polyclonal Antibody at dilution 1:35)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using SLC7A9 Polyclonal Antibody at dilution 1:35)

Related Product Information for anti-SLC7A9 antibody

This gene encodes a protein that belongs to a family of light subunits of amino acid transporters. This protein plays a role in the high-affinity and sodium-independent transport of cystine and neutral and dibasic amino acids, and appears to function in the reabsorption of cystine in the kidney tubule. Mutations in this gene cause non-type I cystinuria, a disease that leads to cystine stones in the urinary system due to impaired transport of cystine and dibasic amino acids. Alternate transcript variants, which encode the same protein, have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 24020985
• NCBI GeneID: 11136
• Molecular Weight: 53,481 Da
• NCBI Official Full Name: SLC7A9
• NCBI Official Synonym Full Names: solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
• NCBI Official Symbol: SLC7A9
• NCBI Official Synonym Symbols: BAT1; CSNU3
• NCBI Protein Information: B(0,+)-type amino acid transporter 1; B(0,+)-type amino acid transporter 1; b(0,+)AT; glycoprotein-associated amino acid transporter b0,+AT1; solute carrier family 7 (cationic amino acid transporter, y+ system), member 9; solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9
• UniProt Protein Name: b(0,+)-type amino acid transporter 1
• Protein Family: b(0,+)-type amino acid transporter
• UniProt Gene Name: SLC7A9
• UniProt Synonym Gene Names: BAT1; b(0,+)AT1
• UniProt Entry Name: BAT1_HUMAN

NCBI Description

This gene encodes a protein that belongs to a family of light subunits of amino acid transporters. This protein plays a role in the high-affinity and sodium-independent transport of cystine and neutral and dibasic amino acids, and appears to function in the reabsorption of cystine in the kidney tubule. Mutations in this gene cause non-type I cystinuria, a disease that leads to cystine stones in the urinary system due to impaired transport of cystine and dibasic amino acids. Alternate transcript variants, which encode the same protein, have been found for this gene. [provided by RefSeq, Jul 2011]

Uniprot Description

SLC7A9: Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high- affinity reabsorption of cystine in the kidney tubule. Defects in SLC7A9 are a cause of non-type I cystinuria (CSNU). CSNU arises from impaired transport of cystine and dibasic amino acids through the epithelial cells of the renal tubule and gastrointestinal tract. Three types of cystinuria have been described: type I (fully recessive or silent); type II (high excretor); type III (moderate excretor). Defects in SLC7A9 are associated with type II and type III cystinuria. They also might account for some non-classic type I cystinuria cases. Belongs to the amino acid-polyamine-organocation (APC) superfamily.

Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: brush border membrane; integral to plasma membrane; apical plasma membrane; plasma membrane

Molecular Function: protein binding; peptide antigen binding; neutral amino acid transmembrane transporter activity; L-cystine transmembrane transporter activity

Biological Process: neutral amino acid transport; L-cystine transport; amino acid transport; ion transport; protein complex assembly; blood coagulation; leukocyte migration; transmembrane transport

Disease: Cystinuria