Western Blot (WB)
(Western blotAll lanes: SLC4A8 antibody at 2ug/ml+ Hela whole cell lysateGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 123,121,118,112,78,84,72 kDaObserved band size: 123 kDa)
Rabbit anti-Human SLC4A8 Polyclonal Antibody | anti-SLC4A8 antibody
SLC4A8 Antibody
Western Blot (WB)
(Western blotAll lanes: SLC4A8 antibody at 2ug/ml+ Hela whole cell lysateGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 123,121,118,112,78,84,72 kDaObserved band size: 123 kDa)
Western Blot (WB)
(Western blotAll lanes: SLC4A8 antibody at 2ug/ml+ Hela whole cell lysateGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 123,121,118,112,78,84,72 kDaObserved band size: 123 kDa)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human salivary gland tissue using MBS7000457 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human salivary gland tissue using MBS7000457 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human thyroid tissue using MBS7000457 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human thyroid tissue using MBS7000457 at dilution of 1:100)
Immunofluorescence (IF)
(Immunofluorescent analysis of Hela cells using MBS7000457 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
Immunofluorescence (IF)
(Immunofluorescent analysis of Hela cells using MBS7000457 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Uniprot Description
SLC4A8: Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity. Belongs to the anion exchanger (TC 2.A.31) family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family; Transporter
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: integral to membrane; neuron projection; plasma membrane
Molecular Function: anion transmembrane transporter activity; inorganic anion exchanger activity
Biological Process: bicarbonate transport; ion transport; sodium ion transport; transmembrane transport
Research Articles on SLC4A8
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Product Notes
The SLC4A8 slc4a8 (Catalog #AAA7000457) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SLC4A8 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SLC4A8 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). Recommended dilution: WB:1:500-2000, IHC:1:20-1:200. Researchers should empirically determine the suitability of the SLC4A8 slc4a8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLC4A8, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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