Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using SLC4A4 antibody.)
Rabbit SLC4A4 Polyclonal Antibody | anti-SLC4A4 antibody
SLC4A4 (Solute Carrier Family 4 Member 4, Sodium Bicarbonate Cotransporter, KNBC, NBC1, NBC2, pNBC, HNBC1, hhNMC, SLC4A5, NBCe1-A) (APC)
WB: 1:500-1:2000
Applications are based on unconjugated antibody.
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using SLC4A4 antibody.)
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using SLC4A4 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemical of paraffin-embedded human liver cancer using SLC4A4 antibody at dilution of 1:200 (400x lens).)
Immunohistochemistry (IHC)
(Immunohistochemical of paraffin-embedded human liver cancer using SLC4A4 antibody at dilution of 1:200 (400x lens).)
Immunohistochemistry (IHC)
(Immunohistochemical of paraffin-embedded human lung cancer using SLC4A4 antibody at dilution of 1:200 (400x lens).)
Immunohistochemistry (IHC)
(Immunohistochemical of paraffin-embedded human lung cancer using SLC4A4 antibody at dilution of 1:200 (400x lens).)
Immunohistochemistry (IHC)
(Immunohistochemical of paraffin-embedded rat lung using SLC4A4 antibody at dilution of 1:200 (400x lens).)
Immunohistochemistry (IHC)
(Immunohistochemical of paraffin-embedded rat lung using SLC4A4 antibody at dilution of 1:200 (400x lens).)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Uniprot Description
SLC4A4: Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. Defects in SLC4A4 are the cause of proximal renal tubular acidosis with ocular abnormalities (pRTA-OA); also known as renal tubular acidosis II. Caused by an impairment of bicarbonate absorption in the proximal tubule, proximal renal tubular acidosis (pRTA) is characterized by a decreased renal HCO3(-) threshold. pRTA-OA is an extremely rare autosomal recessive syndrome characterized by short stature, profound pRTA, mental retardation, bilateral glaucoma, cataracts and bandkeratopathy. Loss of interaction with and stimulation by CA4 is the cause of retinitis pigmentosa type 17 (RP17). Belongs to the anion exchanger (TC 2.A.31) family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 4q21
Cellular Component: basolateral plasma membrane; integral to plasma membrane; plasma membrane
Molecular Function: protein binding; inorganic anion exchanger activity; sodium:bicarbonate symporter activity
Biological Process: transport; bicarbonate transport; regulation of intracellular pH; ion transport; transmembrane transport
Disease: Renal Tubular Acidosis, Proximal, With Ocular Abnormalities And Mental Retardation
Research Articles on SLC4A4
Similar Products
Product Notes
The SLC4A4 slc4a4 (Catalog #AAA6438025) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SLC4A4 (Solute Carrier Family 4 Member 4, Sodium Bicarbonate Cotransporter, KNBC, NBC1, NBC2, pNBC, HNBC1, hhNMC, SLC4A5, NBCe1-A) (APC) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SLC4A4 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). IHC: 1:50-1:200 WB: 1:500-1:2000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the SLC4A4 slc4a4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLC4A4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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