Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using TGFB2 antibody.)
Rabbit TGFB2 Polyclonal Antibody | anti-TGFB2 antibody
TGFB2 Polyclonal Antibody
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using TGFB2 antibody.)
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using TGFB2 antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
Uniprot Description
TGFB2: TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth. Homodimer; disulfide-linked. Heterodimers with TGFB1 and with TGFB3 have been found in bone. Interacts with the serine proteases, HTRA1 and HTRA3. Interacts with ASPN. Belongs to the TGF-beta family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 1q41
Cellular Component: axon; cell soma; extracellular matrix; extracellular region; extracellular space
Molecular Function: beta-amyloid binding; cytokine activity; protein binding; protein heterodimerization activity; protein homodimerization activity; punt binding; receptor binding; receptor signaling protein serine/threonine kinase activity; transforming growth factor beta receptor binding
Biological Process: activation of protein kinase activity; angiogenesis; cardiac muscle cell proliferation; cardioblast differentiation; catagen; cell cycle arrest; cell death; cell migration; cell morphogenesis; cell proliferation; cell-cell signaling; collagen fibril organization; dopamine biosynthetic process; embryonic development; embryonic gut development; epithelial to mesenchymal transition; eye development; generation of neurons; glial cell migration; hair follicle development; hair follicle morphogenesis; heart development; heart morphogenesis; hemopoiesis; intercellular junction assembly and maintenance; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of immune response; negative regulation of Ras protein signal transduction; neuron development; neutrophil chemotaxis; platelet degranulation; positive regulation of cardioblast differentiation; positive regulation of catagen; positive regulation of cell adhesion mediated by integrin; positive regulation of cell cycle; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of heart contraction; positive regulation of immune response; positive regulation of integrin biosynthetic process; positive regulation of neuron apoptosis; positive regulation of ossification; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein secretion; positive regulation of stress-activated MAPK cascade; protein amino acid phosphorylation; regulation of transforming growth factor-beta2 production; response to drug; response to hypoxia; response to progesterone stimulus; response to wounding; salivary gland morphogenesis; SMAD protein nuclear translocation; somatic stem cell division; transforming growth factor beta receptor signaling pathway; uterine wall breakdown; wound healing
Disease: Loeys-dietz Syndrome 4
Research Articles on TGFB2
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Product Notes
The TGFB2 tgfb2 (Catalog #AAA2540045) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TGFB2 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TGFB2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:200 - 1:2000. Researchers should empirically determine the suitability of the TGFB2 tgfb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TGFB2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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