Western Blot (WB)
(Western blot analysis of SLC2A5 expression in rat brain extract (lane 1), and K562 whole cell lysates (lane 2). SLC2A5 at 55KD was detected using rabbit anti-SLC2A5 Antigen Affinity purified polyclonal antibody at 0.5ug/mL. The blot was developed using chemiluminescence (ECL) method. )
Rabbit SLC2A5 Polyclonal Antibody | anti-SLC2A5 antibody
Anti-SLC2A5 Antibody
No cross reactivity with other proteins.
No cross reactivity with other proteins.
Immunohistochemisry Paraffin: 0.5-1mug/ml; Tested Species: Human, Rat
Tested Species:In-house tested species with positive results.
By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections.
Other applications have not been tested.
Western Blot (WB)
(Western blot analysis of SLC2A5 expression in rat brain extract (lane 1), and K562 whole cell lysates (lane 2). SLC2A5 at 55KD was detected using rabbit anti-SLC2A5 Antigen Affinity purified polyclonal antibody at 0.5ug/mL. The blot was developed using chemiluminescence (ECL) method. )
Western Blot (WB)
(Western blot analysis of SLC2A5 expression in rat brain extract (lane 1), and K562 whole cell lysates (lane 2). SLC2A5 at 55KD was detected using rabbit anti-SLC2A5 Antigen Affinity purified polyclonal antibody at 0.5ug/mL. The blot was developed using chemiluminescence (ECL) method. )
Immunohistochemistry (IHC)
(SLC2A5 was detected in paraffin-embedded sections of rat intestine cancer tissues using rabbit anti-SLC2A5 Antigen Affinity purified polyclonal antibody at 1ug/mL. The immunohistochemical section was developed using SABC method. )
Immunohistochemistry (IHC)
(SLC2A5 was detected in paraffin-embedded sections of rat intestine cancer tissues using rabbit anti-SLC2A5 Antigen Affinity purified polyclonal antibody at 1ug/mL. The immunohistochemical section was developed using SABC method. )
Immunohistochemistry (IHC)
(SLC2A5 was detected in paraffin-embedded sections of human intestinal cancer tissues using rabbit anti-SLC2A5 Antigen Affinity purified polyclonal antibody at 1 ug/mL. The immunohistochemical section was developed using SABC method. )
Immunohistochemistry (IHC)
(SLC2A5 was detected in paraffin-embedded sections of human intestinal cancer tissues using rabbit anti-SLC2A5 Antigen Affinity purified polyclonal antibody at 1 ug/mL. The immunohistochemical section was developed using SABC method. )
Background: SLC2A5, also known as GLUT5 (Glucose transporter 5), is a fructose transporter expressed on the apical border of enterocytes in the small intestine. The GLUT5 gene is located on chromosome 1. GLUT5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructose's high concentration in the intestinal lumen. GLUT5 is also expressed in skeletal muscle, testis, kidney, fat tissue, and brain. Fructose malabsorption or Dietary Fructose Intolerance is a dietary disability of the small intestine, where the amount of fructose carrier in enterocytes is deficient.
2. Davidson, N. O., Hausman, A. M. L., Ifkovits, C. A., Buse, J. B., Gould, G. W., Burant, C. F., Bell, G. I.Human intestinal glucose transporter expression and localization of GLUT5.Am. J. Physiol. 262: C795-C800, 1992.
3. Kayano, T., Burant, C. F., Fukumoto, H., Gould, G. W., Fan, Y. S., Eddy, R. L., Byers, M. G., Shows, T. B., Seino, S., Bell, G. I.Human facilitative glucose transporters: isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6).J. Biol. Chem. 265: 13276-13282, 1990.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption. [provided by RefSeq, Jun 2016]
Uniprot Description
GLUT5: an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Plays an important role in fructose absorption by the intestine. Expressed primarily in the jejunal region of the small intestine. Expressed at low levels in human kidney, skeletal muscle, adipocytes, microglial cells and in the human blood-brain barrier.
Protein type: Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass; Transporter
Chromosomal Location of Human Ortholog: 1p36.2
Cellular Component: apical plasma membrane; integral to plasma membrane; plasma membrane; sarcolemma
Molecular Function: fructose transmembrane transporter activity; glucose transmembrane transporter activity
Biological Process: carbohydrate metabolic process; fructose transport; glucose transport; hexose transport; regulation of systemic arterial blood pressure mediated by a chemical signal; response to fructose stimulus
Research Articles on SLC2A5
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Product Notes
The SLC2A5 slc2a5 (Catalog #AAA178460) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-SLC2A5 Antibody reacts with Human, Rat No cross reactivity with other proteins. and may cross-react with other species as described in the data sheet. AAA Biotech's SLC2A5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Western Blot: 0.1-0.5mug/ml; Tested Species: Human, Rat Immunohistochemisry Paraffin: 0.5-1mug/ml; Tested Species: Human, Rat Tested Species:In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Researchers should empirically determine the suitability of the SLC2A5 slc2a5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLC2A5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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